Document Detail

Increase in experimental infarct size with digoxin in a canine model of myocardial ischemia-reperfusion injury.
MedLine Citation:
PMID:  3376834     Owner:  NLM     Status:  MEDLINE    
In the present study, dogs were pretreated with intravenous digoxin, 0.0125 mg/kg/day, for 6 to 7 consecutive days to achieve clinically relevant serum concentrations; untreated animals were used as control subjects. After pretreatment, nine digoxin-pretreated dogs and nine control dogs were anesthetized and subjected to a 60-minute occlusion of the left circumflex coronary artery, followed by 6 hours of reperfusion. Anatomic myocardial infarct size, expressed as a percentage of the areas at risk of infarction and as a percentage of the total left ventricle were: 20.2 +/- 3.3% control vs 35.4 +/- 6.2% digoxin-pretreated (p less than 0.05) and 8.6 +/- 1.3% control vs 14.7 +/- 2.5% digoxin-pretreated (p less than 0.05), respectively (2.04 +/- 0.37 ng/ml serum digoxin). Regional myocardial blood flow in the nonischemic and ischemic zones tended to be lower in digoxin-pretreated than in control animals at baseline testing and were significantly reduced in the anterior subendocardial sites of digoxin-pretreated dogs during ischemia and reperfusion. These data suggest that an exacerbation or enhancement of myocardial ischemia-reperfusion injury may occur in the presence of clinically observable serum digoxin concentrations.
J J Lynch; P J Simpson; K P Gallagher; T B McClanahan; K A Lee; B R Lucchesi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  115     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-28     Completed Date:  1988-06-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1171-82     Citation Subset:  AIM; IM    
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109.
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MeSH Terms
Blood Pressure / drug effects
Coronary Circulation / drug effects
Digoxin / administration & dosage,  blood,  toxicity*
Myocardial Infarction / blood,  pathology*,  physiopathology
Myocardium / pathology*
Potassium / blood
Sodium / blood
Grant Support
Reg. No./Substance:
20830-75-5/Digoxin; 7440-09-7/Potassium; 7440-23-5/Sodium

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