Document Detail

Increase in dopamine metabolites in murine striatum after oral exposure to inorganic but not organic form of selenium.
MedLine Citation:
PMID:  10790499     Owner:  NLM     Status:  MEDLINE    
Selenium (Se) is an essential as well as a toxic trace element. Se intoxication has been reported in both livestock and humans. The central nervous system is sensitive to Se poisoning; exposure to Se causes blind staggers in cattle, poliomyelomalacia in pigs, and nervous system disorders in humans. Differences in neurotoxicity between inorganic and organic Se have been demonstrated. In this study, groups of five male BALB/c mice each were administered sodium selenite or selenomethionine in drinking water ad libitum at 0, 1, 3, and 9 ppm as Se for 14 days. At the end of Se exposure, their brains were removed and dissected into different regions. The concentration of norepinephrine (NE), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT), and 5-hydroxyindolacetic acid (5-HIAA) were determined in each brain region. Food and water consumption and body weight gain were significantly decreased in the group treated with the highest concentration of sodium selenite. In mice administered sodium selenite at 3 and 9 ppm, DOPAC was significantly higher in the striatum than in the control group. The striatal HVA was also increased in the group treated with 3 ppm Se; the DA showed a similar pattern, but the increase was not statistically significant. No alterations of NE, 5-HT, or 5-HIAA levels were detected in any brain region of mice treated with sodium selenite. No significant differences in any parameter among the groups treated with selenomethionine were observed indicating that inorganic Se was more neurotoxic than organic Se via drinking water. The alterations of DA metabolites by inorganic Se in DA-rich striatum suggested a Se-specific increased neural activity of dopaminergic pathways. Results may be useful in further elucidation of neurotoxicity of Se and in establishing a safe level of intake for this element.
M Tsunoda; V J Johnson; R P Sharma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of environmental contamination and toxicology     Volume:  39     ISSN:  0090-4341     ISO Abbreviation:  Arch. Environ. Contam. Toxicol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-07-12     Completed Date:  2000-07-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0357245     Medline TA:  Arch Environ Contam Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA.
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MeSH Terms
Administration, Oral
Body Weight / drug effects
Dopamine / metabolism*
Inorganic Chemicals / toxicity*
Mice, Inbred BALB C
Neostriatum / drug effects*,  metabolism
Organoselenium Compounds / toxicity*
Selenium / toxicity*
Reg. No./Substance:
0/Inorganic Chemicals; 0/Organoselenium Compounds; 7782-49-2/Selenium

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