Document Detail


Increase in cerebral perfusion pressure by arterial hypertension in brain swelling. A mathematical model of the volume-pressure relationship.
MedLine Citation:
PMID:  1117325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brain swelling was produced in monkeys and cats by the inflation af an epidural balloon against the parietal lobe. Resulting changes in intracranial pressure (ICP) were correlated to variation in systemic arterial pressure (SAP). Intracranial perfusion pressure (ICPP) defined as the difference between SAP and ICP, was found to vary with the degree of arterial hyper-and hypotension. The relationship between SAP and ICP can be explained by an existing equilibrium between extramural pressure and vessel wall circumferential tension. A positive perfusion pressure can exist in brain swelling as long as vessel wall tension is preserved and the degree of expanding brain tissue volume is held below certain limits.
Authors:
F Matakas; R Von Waechter; R Knüpling; S J Potolicchio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  42     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-06-13     Completed Date:  1975-06-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  282-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Brain Diseases* / physiopathology
Cats
Cerebrospinal Fluid*
Cerebrovascular Circulation*
Dilatation
Disease Models, Animal*
Hydrocephalus / physiopathology
Intracranial Pressure*
Intubation
Macaca
Mathematics
Papio

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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