Document Detail

Increase in cardiac output with rate-responsive pacemaker.
MedLine Citation:
PMID:  3741016     Owner:  NLM     Status:  MEDLINE    
Patients with myocardial insufficiency or patients during high cardiac work loads increase cardiac output (CO) only through an increase in heart rate (HR), which is not possible with a VVI pacemaker. This clinical study tests the hypothesis that the respiratory-dependent pacemaker (RDP) is able to increase CO by an increase in HR. A multiprogrammable RDP (BIOrate RDP 2, Alpha, Köln, West Germany) was implanted in 21 patients (16 men and 5 women) for ventricular pacing. The mean age of the patients was 68.1 +/- 9.5 years (+/- standard deviation). Since the RDP can be programmed either in the RDP or VVI mode, all patients served as their own control. During follow-up examinations 4 to 6 weeks after implantation, an exercise ECG and a determination of CO during rest and exercise using equilibrium-radionuclide ventriculography were performed. One pacemaker has had to be explanted because of "end of life." No other RDP is malfunctioning. There was a significant increase in HR in all patients during exercise with the RDP versus the VVI mode (105.5 +/- 5.9 versus 84.5 +/- 7.0 bpm; p less than 0.05). CO increased during exercise to 10.6 +/- 0.8 L/min (VVI mode) and 12.7 +/- 1.5 L/min (RDP mode) (p = not significant). RDPs are reliable systems for patients in whom dual-chambered pacemakers are contraindicated (e.g., patients with bradyarrhythmias). The RDPs are able to increase CO by 26 to 35% compared with the VVI mode because of an increase in HR.
F Beyersdorf; J Kreuzer; T A Happ; M Zegelman; P Satter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  42     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-5     Citation Subset:  AIM; IM; S    
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MeSH Terms
Arrhythmias, Cardiac / therapy
Cardiac Output*
Exercise Test
Heart Rate*
Pacemaker, Artificial*
Physical Exertion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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