| Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation. | |
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MedLine Citation:
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PMID: 18311499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Few studies have reported changes of bone mineral density (BMD) after parathyroidectomy in patients with persistent hyperparathyroidism after renal transplantation (3 HPT). PATIENTS AND METHODS: We retrospectively analyzed 14 patients who underwent successful parathyroidectomy for 3 HPT and who had available BMD data before and after parathyroidectomy. RESULTS: Median follow-up time was 26 months (IQR: 16.8-40.2). Serum calcium levels decreased significantly after parathyroidectomy (2.32 +/- 0.09 versus 2.66 +/- 0.16 mmol/l; p < 0.01), as did PTH levels (5.1 +/- 3.0 versus 27.8 +/- 23.7 pmol/l; p < 0.01). Nine patients (64%) had a steroid-free immunosuppression at follow-up. Mean increase in BMD was 9.5 +/- 8.0% for the spine and 9.5 +/- 7.9% for the hip (p < 0.01 for both sites). Patients with osteoporosis (T-score <or= 2.5) or osteopenia (T-score <or= 1) before parathyroidectomy had the biggest increase in BMD (10.7 +/- 7.7% in hip BMD and of 12.3 +/- 8.1% in spine BMD). CONCLUSIONS: Parathyroidectomy is an efficient treatment of osteoporosis and osteopenia in patients with 3 HPT. |
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Authors:
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Stéphane Collaud; Tania Staub-Zähner; Andrea Trombetti; Thomas Clerici; Nicola Marangon; Isabelle Binet; Patrick O Myers; René Rizzoli; Pierre-Yves Martin; John H Robert; Frederic Triponez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of surgery Volume: 32 ISSN: 0364-2313 ISO Abbreviation: World J Surg Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-30 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704052 Medline TA: World J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1795-801 Citation Subset: IM |
Affiliation:
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Department of Thoracic and Endocrine Surgery, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211 Geneva, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Density
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physiology* Female Humans Hyperparathyroidism / etiology*, physiopathology, surgery* Kidney Transplantation* Male Middle Aged Parathyroidectomy* Retrospective Studies Treatment Outcome |
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