Document Detail

Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation.
MedLine Citation:
PMID:  18311499     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Few studies have reported changes of bone mineral density (BMD) after parathyroidectomy in patients with persistent hyperparathyroidism after renal transplantation (3 HPT). PATIENTS AND METHODS: We retrospectively analyzed 14 patients who underwent successful parathyroidectomy for 3 HPT and who had available BMD data before and after parathyroidectomy. RESULTS: Median follow-up time was 26 months (IQR: 16.8-40.2). Serum calcium levels decreased significantly after parathyroidectomy (2.32 +/- 0.09 versus 2.66 +/- 0.16 mmol/l; p < 0.01), as did PTH levels (5.1 +/- 3.0 versus 27.8 +/- 23.7 pmol/l; p < 0.01). Nine patients (64%) had a steroid-free immunosuppression at follow-up. Mean increase in BMD was 9.5 +/- 8.0% for the spine and 9.5 +/- 7.9% for the hip (p < 0.01 for both sites). Patients with osteoporosis (T-score <or= 2.5) or osteopenia (T-score <or= 1) before parathyroidectomy had the biggest increase in BMD (10.7 +/- 7.7% in hip BMD and of 12.3 +/- 8.1% in spine BMD). CONCLUSIONS: Parathyroidectomy is an efficient treatment of osteoporosis and osteopenia in patients with 3 HPT.
Stéphane Collaud; Tania Staub-Zähner; Andrea Trombetti; Thomas Clerici; Nicola Marangon; Isabelle Binet; Patrick O Myers; René Rizzoli; Pierre-Yves Martin; John H Robert; Frederic Triponez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  32     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-30     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1795-801     Citation Subset:  IM    
Department of Thoracic and Endocrine Surgery, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211 Geneva, Switzerland.
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MeSH Terms
Bone Density / physiology*
Hyperparathyroidism / etiology*,  physiopathology,  surgery*
Kidney Transplantation*
Middle Aged
Retrospective Studies
Treatment Outcome

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