| Increase in the blood pressure of rats chronically fed low levels of lead. | |
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MedLine Citation:
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PMID: 3203629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Groups of 15 to 18 female weanling Long-Evans rats fed a rye-based diet low in lead (0.25 ppm) were exposed to 0.1, 1.0, and 5.0 ppm lead in drinking water. No suggestion of clinical lead toxicity was recognized. Systolic pressures were measured at 3-month intervals after weaning. The groups of lead-exposed animals had consistently and significantly higher average pressures than control animals, the increase approximating 15 mm Hg. With the lowest lead exposure (0.1 ppm), the increase in average pressure was gradual, being half minimal at 3 months and requiring 1 year to become maximal. After 1 year, half of these rats had pressures from 0 to 10 mm Hg above the control average; 40, 20, and 10% had pressures that were 20, 30, and 40 mm Hg, respectively, above the control average. Thus, rats exposed to lead in amounts comparable to the environmental exposure of many Americans had an average elevation in systolic pressure comparable to that of human beings with essential hypertension. |
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Authors:
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H M Perry; M W Erlanger; E F Perry |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Environmental health perspectives Volume: 78 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1989-02-06 Completed Date: 1989-02-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 107-11 Citation Subset: IM |
Affiliation:
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Department of Medicine, Washington-University School of Medicine, St. Louis, MO 63110. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Blood Pressure / drug effects* Female Lead / administration & dosage, pharmacology* Rats |
| Chemical | |
Reg. No./Substance:
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7439-92-1/Lead |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 6 Year: 1988 Volume: 78First Page: 107 Last Page: 111 ID: 1474601 PubMed Id: 3203629 |
| Increase in the blood pressure of rats chronically fed low levels of lead. | |
| H M Perry, Jr | |
| M W Erlanger | |
| E F Perry | |
| Department of Medicine, Washington-University School of Medicine, St. Louis, MO 63110. |
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