Document Detail


Increase in the acute toxicity and brain concentrations of chlorophenoxyacetic acids by probenecid in rats.
MedLine Citation:
PMID:  2276599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Probenecid increased the acute toxicity of chlorophenoxyacetic acids (2,4-D, 2,4,5-T and MCPA) in rats. 2. Probenecid increased the brain to plasma ratios of all the three 14C-labelled chlorophenoxyacetic acids. The increase was due only partly to the displacement of chlorophenoxyacids from their binding sites in rat plasma proteins by probenecid. 3. Probenecid did not change significantly the intracerebral distribution pattern of 14C-labelled chlorophenoxyacetic acids.
Authors:
P Ylitalo; U Närhi; H A Elo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  21     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-03-01     Completed Date:  1991-03-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  811-4     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, University of Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
2,4,5-Trichlorophenoxyacetic Acid / metabolism,  toxicity
2,4-Dichlorophenoxyacetic Acid / metabolism,  toxicity
2-Methyl-4-chlorophenoxyacetic Acid / metabolism,  toxicity
Animals
Blood Proteins / metabolism
Brain / drug effects,  metabolism*
Male
Probenecid / pharmacology*
Protein Binding
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Blood Proteins; 57-66-9/Probenecid; 93-76-5/2,4,5-Trichlorophenoxyacetic Acid; 94-74-6/2-Methyl-4-chlorophenoxyacetic Acid; 94-75-7/2,4-Dichlorophenoxyacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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