| Increase in the acute toxicity and brain concentrations of chlorophenoxyacetic acids by probenecid in rats. | |
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MedLine Citation:
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PMID: 2276599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Probenecid increased the acute toxicity of chlorophenoxyacetic acids (2,4-D, 2,4,5-T and MCPA) in rats. 2. Probenecid increased the brain to plasma ratios of all the three 14C-labelled chlorophenoxyacetic acids. The increase was due only partly to the displacement of chlorophenoxyacids from their binding sites in rat plasma proteins by probenecid. 3. Probenecid did not change significantly the intracerebral distribution pattern of 14C-labelled chlorophenoxyacetic acids. |
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Authors:
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P Ylitalo; U Närhi; H A Elo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: General pharmacology Volume: 21 ISSN: 0306-3623 ISO Abbreviation: Gen. Pharmacol. Publication Date: 1990 |
Date Detail:
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Created Date: 1991-03-01 Completed Date: 1991-03-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7602417 Medline TA: Gen Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 811-4 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, University of Kuopio, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2,4,5-Trichlorophenoxyacetic Acid
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metabolism,
toxicity 2,4-Dichlorophenoxyacetic Acid / metabolism, toxicity 2-Methyl-4-chlorophenoxyacetic Acid / metabolism, toxicity Animals Blood Proteins / metabolism Brain / drug effects, metabolism* Male Probenecid / pharmacology* Protein Binding Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 57-66-9/Probenecid; 93-76-5/2,4,5-Trichlorophenoxyacetic Acid; 94-74-6/2-Methyl-4-chlorophenoxyacetic Acid; 94-75-7/2,4-Dichlorophenoxyacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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