Document Detail

Increase in the acute toxicity and brain concentrations of chlorophenoxyacetic acids by probenecid in rats.
MedLine Citation:
PMID:  2276599     Owner:  NLM     Status:  MEDLINE    
1. Probenecid increased the acute toxicity of chlorophenoxyacetic acids (2,4-D, 2,4,5-T and MCPA) in rats. 2. Probenecid increased the brain to plasma ratios of all the three 14C-labelled chlorophenoxyacetic acids. The increase was due only partly to the displacement of chlorophenoxyacids from their binding sites in rat plasma proteins by probenecid. 3. Probenecid did not change significantly the intracerebral distribution pattern of 14C-labelled chlorophenoxyacetic acids.
P Ylitalo; U Närhi; H A Elo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  21     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-03-01     Completed Date:  1991-03-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  811-4     Citation Subset:  IM    
Department of Pharmacology and Toxicology, University of Kuopio, Finland.
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MeSH Terms
2,4,5-Trichlorophenoxyacetic Acid / metabolism,  toxicity
2,4-Dichlorophenoxyacetic Acid / metabolism,  toxicity
2-Methyl-4-chlorophenoxyacetic Acid / metabolism,  toxicity
Blood Proteins / metabolism
Brain / drug effects,  metabolism*
Probenecid / pharmacology*
Protein Binding
Rats, Inbred Strains
Reg. No./Substance:
0/Blood Proteins; 57-66-9/Probenecid; 93-76-5/2,4,5-Trichlorophenoxyacetic Acid; 94-74-6/2-Methyl-4-chlorophenoxyacetic Acid; 94-75-7/2,4-Dichlorophenoxyacetic Acid

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