| Increase in Transaminase Levels Following the Use of Raltegravir in a Woman With a High HIV Viral Load at 35 Weeks of Pregnancy. | |
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MedLine Citation:
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PMID: 23343800 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Despite the efficacy of raltegravir in reducing viral load in HIV-infected patients, evidence for its safety in late pregnancy is lacking. A high rate of placental transfer was recently demonstrated. Case: A treatment-naïve 34-year-old HIV-1-positive woman of African origin began treatment with zidovudine/lamivudine, lopinavir/ritonavir, and raltegravir at 35 weeks of pregnancy. After 11 days of treatment with raltegravir, a substantial reduction in viral load was achieved. Concurrently, she had a 23-fold increase in serum alanine aminotransferase and a 10-fold increase in serum aspartate aminotransferase, both of which returned to normal when raltegravir treatment was discontinued. A healthy boy was delivered at term. The infant's tests for HIV were negative at five months, and he had no health problems at eight months. Conclusion: This is the first case report, to our knowledge, of increased maternal serum transaminase levels following the use of raltegravir in a woman at a late stage of pregnancy. |
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Authors:
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Sophie Renet; Aurélie Closon; Marie-Sophie Brochet; Jean-François Bussières; Marc Boucher |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC Volume: 35 ISSN: 1701-2163 ISO Abbreviation: J Obstet Gynaecol Can Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101126664 Medline TA: J Obstet Gynaecol Can Country: Canada |
Other Details:
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Languages: eng Pagination: 68-72 Citation Subset: IM |
Affiliation:
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Pharmacy Practice Research Unit (PPRU), CHU Sainte-Justine, Montreal QC, Pharmacy Department, Paris-Descartes University, Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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