Document Detail

Increase brain lactate in hepatic encephalopathy: cause or consequence?
MedLine Citation:
PMID:  20600436     Owner:  NLM     Status:  MEDLINE    
Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome which develops as a result of liver failure or disease. Increased concentrations of brain lactate (microdialysate, cerebrospinal fluid, tissue) are commonly measured in patients with HE induced by either acute or chronic liver failure. Whether an increase in brain lactate is a cause or a consequence of HE remains undetermined. A rise in cerebral lactate may occur due to (1) blood-borne lactate (hyperlactataemia) crossing the blood-brain barrier, (2) increased glycolysis due to energy failure or impairment and (3) increased lactate production/release or decreased lactate utilization/uptake. This review explores the different reasons for lactate accumulation in the brain during liver failure and describes the possible roles of lactate in the pathogenesis of HE.
Christopher F Rose
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-02
Journal Detail:
Title:  Neurochemistry international     Volume:  57     ISSN:  1872-9754     ISO Abbreviation:  Neurochem. Int.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  389-94     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Neuroscience Research Unit, CRCHUM, Hôpital Saint-Luc, Université de Montréal, Montréal, Québec, Canada.
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MeSH Terms
Biological Transport, Active / physiology
Brain Chemistry / physiology*
Brain Edema / metabolism,  pathology
Energy Metabolism / physiology
Hepatic Encephalopathy / metabolism*,  pathology*
Lactic Acid / blood,  cerebrospinal fluid,  metabolism*
Reg. No./Substance:
50-21-5/Lactic Acid

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