Document Detail


Increase of brain endogenous monoamine oxidase inhibitory activity (tribulin) in experimental audiogenic seizures in rats: evidence for a monoamine oxidase A inhibiting component of tribulin.
MedLine Citation:
PMID:  1417943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brain tribulin activity in rats with an inherited predisposition to audiogenic epilepsy was studied after seizures of different intensity were induced by an electric bell. Weak seizures (from 0 to 2 arbitrary units) did not produce any changes in endogenous inhibitory activity towards either monoamine oxidase (MAO) A or B. Moderate seizures were characterized by increases in both MAO A and MAO B inhibitory activity (up to 1.9-fold). Complete tonic epileptiform seizures with total areflexia (4 arbitrary units) induced further augmentation (up to 2.5-fold) of MAO A but not of MAO B inhibitory activity. This dissociation between the two inhibitory activities points to the existence of a separate MAO A-inhibiting component of brain tribulin which is different from isatin.
Authors:
A E Medvedev; V Z Gorkin; I B Fedotova; A F Semiokhina; V Glover; M Sandler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  44     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-13     Completed Date:  1992-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1209-10     Citation Subset:  IM    
Affiliation:
Institute of Biological and Medical Chemistry, Academy of Medical Sciences, Moscow, Russia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry*
Isatin / metabolism
Monoamine Oxidase / metabolism*
Monoamine Oxidase Inhibitors / metabolism*
Rats
Rats, Inbred Strains / genetics*
Rats, Wistar
Seizures / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Monoamine Oxidase Inhibitors; 84788-92-1/tribulin; 91-56-5/Isatin; EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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