| Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes. Systematic review and meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 21645195 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background. Insulin treatment is accompanied by weight increase in type 2 diabetes mellitus. Aim. Aim of this systematic review and meta-analysis was to evaluate body weight increase and its clinical correlates, through direct weighted regressions, as well as the effect of different insulin regimens and insulin analogs, through meta-analysis. Methods. Appropriate methodology according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was adhered to. 46 randomized studies, published as full papers, reporting the effect of insulin treatment on change in body weight were identified, and used to identify predictors of weight change; studies were included in a meta-analysis to study the effect of different insulin regimens or insulin analogs on weight change Results. Intensity of treatment [aim of study (fasting blood glucose, mg/dl), dose of insulin, final HbA1c, change of HbA1c, and frequency of hypoglycaemia] was significantly associated with body weight increase, with small differences between basal versus twice-a-day and prandial regimen. At meta-analysis, body weight increase was lower with basal regimen than with twice-a-day regimen and than with a prandial regimen. Within all regimens, body weight increase was lower with detemir than with NPH, with no difference between glargine and NPH; only two studies directly compared detemir and glargine, indicating lower weight gain with the former insulin. Within twice-a-day regimens and within prandial regimens, comparison was between newer analogs and older drugs, with no significant difference in body weight increase. Conclusion. Body weight increase during the first year of insulin treatment is associated with intensity of treatment; body weight increase also depends on the insulin regimen applied. |
| | |
Authors:
|
A E Pontiroli; L Miele; A Morabito |
Related Documents
:
|
1612555 - Peripheral glucose metabolism in patients with insulin resistance and acanthosis nigric... 9837775 - Effect of extracellular palmitate on 2-deoxy-d-glucose uptake in muscle from ad libitum... 16171885 - Gene therapy for diabetes mellitus in rats by intramuscular injection of lentivirus con... 19740975 - Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute ... 12359385 - Self-management and well-being in adolescents with diabetes mellitus: do illness repres... 14516935 - Monogenic forms of insulin resistance: apertures that expose the common metabolic syndr... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-3 |
Journal Detail:
|
Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Cattedra di Medicina Interna e Cattedra di Biometria, Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Milano, and Ospedale San Paolo, Milano, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synergies between climate anomalies and hydrological modifications facilitate estuarine biotic invas...
Next Document: Acute systemic inflammation induced by influenza A (H1N1) vaccination causes a deterioration in endo...