Document Detail

Increase of S-100 immunoreactivity in the urinary bladder from patients with multiple sclerosis, an indication of peripheral neuronal lesion.
MedLine Citation:
PMID:  6391146     Owner:  NLM     Status:  MEDLINE    
The Schwann cells in urinary bladder biopsies from multiple sclerosis patients and controls were examined by immunocytochemistry with an antiserum to S-100. S-100 immunoreactivity was found to be markedly increased in these tissues as compared with the controls, indicating a Schwann cell hyperplasia in the urinary bladder in multiple sclerosis. This finding suggests that local neuronal damage exists in the urinary bladder of patients with multiple sclerosis. Therefore, the concept of multiple sclerosis as a disease wholly of the central nervous system should be reexamined.
J Gu; J M Polak; A Deane; D Cocchia; F Michetti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  82     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-03     Completed Date:  1985-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  649-54     Citation Subset:  AIM; IM    
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MeSH Terms
Fluorescent Antibody Technique
Multiple Sclerosis / metabolism*,  pathology,  physiopathology
Peripheral Nerves / pathology*
S100 Proteins / analysis*
Schwann Cells / immunology,  pathology
Urinary Bladder / immunology,  pathology*
Reg. No./Substance:
0/S100 Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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