Document Detail


Increase of NKG2D ligands and sensitivity to NK cell-mediated cytotoxicity of tumor cells by heat shock and ionizing radiation.
MedLine Citation:
PMID:  17079863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we have investigated if current cancer therapeutic modalities including hyperthermia and ionizing radiation can increase the expression of NKG2D ligands in human cancer cell lines. The expressions of NKG2D ligands were induced by both heat shock and ionizing radiation in various cell lines including KM12, NCI-H23, HeLa and A375 cells with peaks at 2 h and 9 h after treatment, respectively, although inducibility of each NKG2D ligand was various depending on cell lines. During the induction of NKG2D ligands, heat shock protein 70 was induced by heat shock but not by ionizing radiation. These results were followed by increased susceptibilities to NK cell-mediated cytolysis after treatment with heat shock and ionizing radiation. These results suggest that heat shock and ionizing radiation induce NKG2D ligands and consequently might lead to increased NK cell-mediated cytotoxicity in various cancer cells.
Authors:
Joo-Young Kim; Young-Ok Son; Soon-Won Park; Jae-Ho Bae; Joo Seop Chung; Hyung Hoi Kim; Byung-Seon Chung; Sun-Hee Kim; Chi-Dug Kang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental & molecular medicine     Volume:  38     ISSN:  1226-3613     ISO Abbreviation:  Exp. Mol. Med.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-02     Completed Date:  2007-02-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9607880     Medline TA:  Exp Mol Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  474-84     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Pusan National University School of Medicine, Busan 602-739, Korea.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Surface / metabolism,  radiation effects
Cytotoxicity, Immunologic / physiology*,  radiation effects*
Gene Expression Regulation, Neoplastic / radiation effects
HSP70 Heat-Shock Proteins / metabolism,  radiation effects
Heat-Shock Response* / physiology
Hela Cells
Hot Temperature
Humans
Hyperthermia, Induced / methods
Killer Cells, Natural / immunology*
Ligands*
NK Cell Lectin-Like Receptor Subfamily K
Neoplasms / immunology,  radiotherapy*,  therapy
Radiation, Ionizing
Receptors, Immunologic / metabolism*
Receptors, Natural Killer Cell
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antigens, Surface; 0/HSP70 Heat-Shock Proteins; 0/KLRK1 protein, human; 0/Ligands; 0/NK Cell Lectin-Like Receptor Subfamily K; 0/Receptors, Immunologic; 0/Receptors, Natural Killer Cell

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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