Document Detail


Increase of the IL-1 beta and IL-6 levels in CSF in patients with vasospasm following aneurysmal SAH.
MedLine Citation:
PMID:  15159698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines play a key role in mutual influence of the immunological, endocrine and CNS systems. It has been proven that proinflammatory ILs may intensify the cascade of biochemical changes in ischemic brain damage. Vasospasm, which may accompany SAH and often coexists with symptoms of DINDs, is the cause of ischemic changes in the brain. It is thought that immunological mechanisms may be one of the causes of degenerative-productive changes in vessel walls, in delayed vasospasm following SAH, which lead to substantial vasospasm and in consequence too cerebral ischemia. In the randomly selected group of patients, who underwent surgical treatment after aneurysmal SAH, we determined the concentration of IL-1 beta and IL-6 in CSF in the periods between Days 0 to 3; 4 to 7; and 8 to 15 after the occurrence of SAH. The presence and dynamics of development of vasospasm were assessed on the basis of increasing DINDs as well as CT and cerebral angiography. We examined the concentrations of ILs in CSF using radioimmunological methods, applying commercially available tests for their assessment. We found that in the period between 8 and 15 days after SAH, in increasing delayed vasospasm and DINDs, here is a statistically significant increase concentration of IL-1 beta in CSF (105.4 +/- 46.9 pg x ml-1; p<0.005), and no significant changes in patients without vasospasm and neurological deficits. On the other hand, we noted a statistically significant increase concentration of IL-6 in CSF (4802 +/- 1170 ng x ml-1; p<0.05) only in the acute phase after SAH (Days 0-3) in patients in poor clinical condition, in whom delayed vasospasm and cerebral ischemia developed later. This increase of ILs level in CSF is probably related to the intensity of the SAH, and secondarily aggravates the vasospasm and ischemic changes in the brain.
Authors:
Stanislaw Hendryk; Barbara Jarzab; Jadwiga Josko
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  25     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:    2004 Feb-Apr
Date Detail:
Created Date:  2004-05-25     Completed Date:  2004-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery and Neurotraumatology, Silesian Medical University, Bytom, Poland. neursurg@infomed.slam.katowice.pl
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MeSH Terms
Descriptor/Qualifier:
Brain Ischemia / cerebrospinal fluid*,  etiology
Humans
Interleukin-1 / cerebrospinal fluid*
Interleukin-6 / cerebrospinal fluid*
Intracranial Aneurysm / cerebrospinal fluid*,  complications
Rupture, Spontaneous
Subarachnoid Hemorrhage / cerebrospinal fluid*,  complications
Time Factors
Vasospasm, Intracranial / cerebrospinal fluid*,  complications
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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