Document Detail


Incorporation of unnatural amino acids for synthetic biology.
MedLine Citation:
PMID:  20024068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The challenge of synthetic biology lies in the construction of artificial cellular systems. This requires the development of modular "parts" that can be integrated into living systems to elicit an artificial, yet programmed, response or function. The development of methods to engineer proteins bearing unnatural amino acids (UAAs) provides essential components that may address this challenge. Here we review the emerging strategies for incorporating UAAs into proteins with the endgame of engineering artificial cells and organisms.
Authors:
Natalya Voloshchuk; Jin Kim Montclare
Related Documents :
4382008 - The effects of potassium ions and denervation on protein synthesis and the transport of...
23280038 - Analysis of cannabinoids in laser-microdissected trichomes of medicinal cannabis sativa...
11904428 - Metabolic efficiency and amino acid composition in the proteomes of escherichia coli an...
20758 - Inhibitory effect of mercaptoamino acids on lysino-alanine formation during alkali trea...
24874568 - Adaptation of a cyanobacterium to a biochemically rich environment in experimental evol...
3084488 - Calcium-dependent oxidation of 5,8,11-icosatrienoic acid by the cyclooxygenase enzyme s...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2009-09-04
Journal Detail:
Title:  Molecular bioSystems     Volume:  6     ISSN:  1742-2051     ISO Abbreviation:  Mol Biosyst     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-23     Completed Date:  2010-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251620     Medline TA:  Mol Biosyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  65-80     Citation Subset:  IM    
Affiliation:
Department of Chemical and Biological Sciences, Polytechnic Institute of New York University, Brooklyn, NY 11201, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*,  genetics,  metabolism*
Biology / methods*
Models, Genetic
Models, Theoretical
Protein Engineering / methods*
Chemical
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Predicting protein-protein interactions in the context of protein evolution.
Next Document:  Molecular recognition of poly(A) targeting by protoberberine alkaloids: in vitro biophysical studies...