Document Detail

Incorporation of unnatural amino acids for synthetic biology.
MedLine Citation:
PMID:  20024068     Owner:  NLM     Status:  MEDLINE    
The challenge of synthetic biology lies in the construction of artificial cellular systems. This requires the development of modular "parts" that can be integrated into living systems to elicit an artificial, yet programmed, response or function. The development of methods to engineer proteins bearing unnatural amino acids (UAAs) provides essential components that may address this challenge. Here we review the emerging strategies for incorporating UAAs into proteins with the endgame of engineering artificial cells and organisms.
Natalya Voloshchuk; Jin Kim Montclare
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2009-09-04
Journal Detail:
Title:  Molecular bioSystems     Volume:  6     ISSN:  1742-2051     ISO Abbreviation:  Mol Biosyst     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-23     Completed Date:  2010-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251620     Medline TA:  Mol Biosyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  65-80     Citation Subset:  IM    
Department of Chemical and Biological Sciences, Polytechnic Institute of New York University, Brooklyn, NY 11201, USA.
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MeSH Terms
Amino Acids / chemistry*,  genetics,  metabolism*
Biology / methods*
Models, Genetic
Models, Theoretical
Protein Engineering / methods*
Reg. No./Substance:
0/Amino Acids

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