Document Detail

Incorporation of side-chain groups of basic amino acids into oligonucleotides via the 2'-position of uridine.
MedLine Citation:
PMID:  17150776     Owner:  NLM     Status:  MEDLINE    
Certain amino acids and short peptides are known to act as enhancers of ribozyme-mediated RNA cleavage at low concentration of magnesium ion. Thus, covalent conjugates of oligonucleotides and some amino acids may have a potential for development as sequence-specific artificial ribonucleases. Here we would like to report an incorporation of basic amino acids, lysine and histidine, into oligonucleotides at the 2'-position of a uridine residue. The approach involves the 2'-O-alkylation and attachment of the corresponding amino acid by the alpha-amino group through a urethane-type linker.
Eugeny M Zubin; Dmitry A Stetsenko; Anna V Kachalova; Michael J Gait; Tatiana S Oretskaya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleic acids symposium series (2004)     Volume:  -     ISSN:  1746-8272     ISO Abbreviation:  Nucleic Acids Symp Ser (Oxf)     Publication Date:  2005  
Date Detail:
Created Date:  2006-12-07     Completed Date:  2007-06-12     Revised Date:  2007-09-19    
Medline Journal Info:
Nlm Unique ID:  101259965     Medline TA:  Nucleic Acids Symp Ser (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-8     Citation Subset:  IM    
Chemistry Department, M. V. Lomonossov Moscow State University, 1 Leninskie Gory, Moscow 119992, Russia.
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MeSH Terms
Amino Acids, Basic / chemistry*
Histidine / chemistry
Lysine / chemistry
Oligonucleotides / chemistry*
Organophosphorus Compounds / chemistry
Uridine / chemistry*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Amino Acids, Basic; 0/Oligonucleotides; 0/Organophosphorus Compounds; 0/phosphoramidite; 56-87-1/Lysine; 58-96-8/Uridine; 71-00-1/Histidine

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