| Incorporation of side-chain groups of basic amino acids into oligonucleotides via the 2'-position of uridine. | |
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MedLine Citation:
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PMID: 17150776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Certain amino acids and short peptides are known to act as enhancers of ribozyme-mediated RNA cleavage at low concentration of magnesium ion. Thus, covalent conjugates of oligonucleotides and some amino acids may have a potential for development as sequence-specific artificial ribonucleases. Here we would like to report an incorporation of basic amino acids, lysine and histidine, into oligonucleotides at the 2'-position of a uridine residue. The approach involves the 2'-O-alkylation and attachment of the corresponding amino acid by the alpha-amino group through a urethane-type linker. |
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Authors:
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Eugeny M Zubin; Dmitry A Stetsenko; Anna V Kachalova; Michael J Gait; Tatiana S Oretskaya |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nucleic acids symposium series (2004) Volume: - ISSN: 1746-8272 ISO Abbreviation: Nucleic Acids Symp Ser (Oxf) Publication Date: 2005 |
Date Detail:
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Created Date: 2006-12-07 Completed Date: 2007-06-12 Revised Date: 2007-09-19 |
Medline Journal Info:
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Nlm Unique ID: 101259965 Medline TA: Nucleic Acids Symp Ser (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 347-8 Citation Subset: IM |
Affiliation:
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Chemistry Department, M. V. Lomonossov Moscow State University, 1 Leninskie Gory, Moscow 119992, Russia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Basic
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chemistry* Histidine / chemistry Lysine / chemistry Oligonucleotides / chemistry* Organophosphorus Compounds / chemistry Uridine / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Basic; 0/Oligonucleotides; 0/Organophosphorus Compounds; 0/phosphoramidite; 56-87-1/Lysine; 58-96-8/Uridine; 71-00-1/Histidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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