Document Detail

Incorporation of saturated fatty acids into phosphatidylcholine bilayers.
MedLine Citation:
PMID:  856286     Owner:  NLM     Status:  MEDLINE    
The transition temperature of dipalmitoylglycerophosphocholine in multi-lamellar aqueous suspensions, as observed by high-sensitivity differential scanning calorimetry, is raised from 41.4 to 61.5 degrees C by addition of palmitic acid at a mole fraction of 0.67. It appears that the fatty acid chains pack in the hexagonal lattice with the lipid chains in a one-to one ratio, thereby eliminating the destabilizing crowding of the phosphatidylcholine head groups. A similar effect on dilauroylglycerophosphocholine is produced by lauric acid. The stabilizing effect is not produced in full measure by acids of different chain lengths, nor by alcohols or saturated hydrocarbons of the same chain length.
S Mabrey; J M Sturtevant
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  486     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  444-50     Citation Subset:  IM    
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MeSH Terms
Membranes, Artificial*
Models, Biological
Palmitic Acids*
Reg. No./Substance:
0/Gels; 0/Membranes, Artificial; 0/Palmitic Acids; 0/Phosphatidylcholines; 0/Phospholipids

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