Document Detail

Incorporation of radioactivity into amino acids and fatty acids after administration of 14C-geranylgeranylacetone to rats.
MedLine Citation:
PMID:  3604254     Owner:  NLM     Status:  MEDLINE    
The radioactive components present in plasma proteins and adipose tissue after oral dosing of 14C-geranylgeranylacetone (GGA) to rats were characterized by gel filtration, paper electrophoresis, t.l.c. and reversed-phase column chromatography. The radioactivity associated with the plasma proteins was identified as 14C-labelled amino acids (Glu, Asp, Ala, Pro, Gly and probably Ser); however, no 14C was detectable in the essential amino acids. Radioactivity accumulated in adipose tissue as 14C-labelled fatty acids of triglycerides. The incorporation of 14C into amino acids and fatty acids may be due to the formation of 14C-propionyl-CoA resulting from omega-oxidation and successive beta-oxidations of 14C-GGA. This view was supported by the finding that 14C-acetate was incorporated into amino acids and fatty acids in a similar manner to 14C-GGA.
Y Nishizawa; H Tanaka; K Kinoshita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  17     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-31     Completed Date:  1987-07-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  469-76     Citation Subset:  IM    
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MeSH Terms
Acetic Acid
Acetic Acids / metabolism
Adipose Tissue / metabolism
Amino Acids / metabolism*
Chromatography, Ion Exchange
Chromatography, Thin Layer
Diterpenes / metabolism*
Electrophoresis, Paper
Fatty Acids / metabolism
Rats, Inbred Strains
Reg. No./Substance:
0/Acetic Acids; 0/Amino Acids; 0/Diterpenes; 0/Fatty Acids; 64-19-7/Acetic Acid; 6809-52-5/geranylgeranylacetone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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