Document Detail

Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids.
MedLine Citation:
PMID:  16115358     Owner:  NLM     Status:  MEDLINE    
The present study investigated whether consuming dairy products naturally enriched in cis-9, trans-11 (c9,t11) conjugated linoleic acid (CLA) by modification of cattle feed increases the concentration of this isomer in plasma and cellular lipids in healthy men. The study had a double-blind cross-over design. Subjects aged 34-60 years consumed dairy products available from food retailers for 1 week and then either control (0.17 g c9,t11 CLA/d; 0.31 g trans-vaccenic acid (tVA)/d) or CLA-enriched (1.43 g c9,t11 CLA/d; 4.71 g tVA/d) dairy products for 6 weeks. After 7 weeks washout, this was repeated with the alternate products. c9,t11 CLA concentration in plasma lipids was lower after consuming the control products, which may reflect the two-fold greater c9,t11 CLA content of the commercial products. Consuming the CLA-enriched dairy products increased the c9,t11 CLA concentration in plasma phosphatidylcholine (PC) (38 %; P = 0.035), triacylglycerol (TAG) (22 %; P < 0.0001) and cholesteryl esters (205 %; P < 0.0001), and in peripheral blood mononuclear cells (PBMC) (238 %; P < 0.0001), while tVA concentration was greater in plasma PC (65 %; P = 0.035), TAG (98 %; P = 0.001) and PBMC (84 %; P = 0.004). Overall, the present study shows that consumption of naturally enriched dairy products in amounts similar to habitual intakes of these foods increased the c9,t11 CLA content of plasma and cellular lipids.
Graham C Burdge; Sabine Tricon; Rebecca Morgan; Kirsty E Kliem; Caroline Childs; Emma Jones; Jennifer J Russell; Robert F Grimble; Christine M Williams; Parveen Yaqoob; Philip C Calder
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  94     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-23     Completed Date:  2005-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  237-43     Citation Subset:  IM    
Institute of Human Nutrition, Biomedical Sciences Building, University of Southhampton, Bassett Crescent East, Southhampton, S016 7PX, UK.
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MeSH Terms
Animal Feed
Cross-Over Studies
Dairy Products*
Double-Blind Method
Food, Fortified*
Leukocytes, Mononuclear / metabolism*
Linoleic Acids, Conjugated / administration & dosage,  blood,  metabolism*
Lipid Metabolism*
Middle Aged
Milk / metabolism
Oleic Acids / administration & dosage,  blood,  metabolism*
Reg. No./Substance:
0/Linoleic Acids, Conjugated; 0/Oleic Acids; 0/cis-9, trans-11-conjugated linoleic acid; 143-25-9/11-octadecenoic acid; 8029-34-3/Butter

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