| Incorporation of casein phosphopeptide-amorphous calcium phosphate into a glass-ionomer cement. | |
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MedLine Citation:
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PMID: 14578505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes have been shown to prevent demineralization and promote remineralization of enamel subsurface lesions in animal and in situ caries models. The aim of this study was to determine the effect of incorporating CPP-ACP into a self-cured glass-ionomer cement (GIC). Incorporation of 1.56% w/w CPP-ACP into the GIC significantly increased microtensile bond strength (33%) and compressive strength (23%) and significantly enhanced the release of calcium, phosphate, and fluoride ions at neutral and acidic pH. MALDI mass spectrometry also showed casein phosphopeptides from the CPP-ACP nanocomplexes to be released. The release of CPP-ACP and fluoride from the CPP-ACP-containing GIC was associated with enhanced protection of the adjacent dentin during acid challenge in vitro. |
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Authors:
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S A Mazzaoui; M F Burrow; M J Tyas; S G Dashper; D Eakins; E C Reynolds |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of dental research Volume: 82 ISSN: 0022-0345 ISO Abbreviation: J. Dent. Res. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-27 Completed Date: 2003-11-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 914-8 Citation Subset: D; IM |
Affiliation:
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School of Dental Science, The University of Melbourne, 711 Elizabeth Street, Melbourne, Victoria 3000, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Calcium / analysis Cariostatic Agents / analysis Caseins* Compressive Strength Dental Bonding* Dental Stress Analysis Dentin Fluorides / analysis Glass Ionomer Cements / chemistry*, therapeutic use Humans Materials Testing Molar Phosphates / analysis Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tensile Strength Tooth Demineralization / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Cariostatic Agents; 0/Caseins; 0/Fluorides; 0/Glass Ionomer Cements; 0/Phosphates; 0/casein phosphopeptide-amorphous calcium phosphate nanocomplex; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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