| Incorporation of antigens into viral capsids augments immunogenicity of adeno-associated virus vector-based vaccines. | |
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MedLine Citation:
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PMID: 23035231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genetic modification of adeno-associated virus (AAV) capsids has previously been exploited to redirect viral tropism. Here we demonstrate that engineering of AAV capsids as scaffolds for antigen display augments antigen-specific immunogenicity. Combining antigen display with vector-mediated overexpression resulted in a single-shot prime-boost vaccine. This new class of vaccines induced immune responses significantly faster and an IgG antibody pool of higher avidity than conventional vectors, highlighting the potency of capsid modification in vaccine development. |
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Authors:
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Jan Rybniker; Angela Nowag; Hanna Janicki; Kai Demant; Pia Hartmann; Hildegard Büning |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-10-03 |
Journal Detail:
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Title: Journal of virology Volume: 86 ISSN: 1098-5514 ISO Abbreviation: J. Virol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-20 Completed Date: 2013-01-28 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 13800-4 Citation Subset: IM |
Affiliation:
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1st Department of Internal Medicine, Division of Infectious Diseases, University Hospital Cologne, Cologne, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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biosynthesis Antigens, Viral / genetics*, immunology Capsid* Dependovirus / genetics* Genetic Vectors* Viral Vaccines / genetics, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Antigens, Viral; 0/Viral Vaccines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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