Document Detail


Incorporation of antigens into viral capsids augments immunogenicity of adeno-associated virus vector-based vaccines.
MedLine Citation:
PMID:  23035231     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic modification of adeno-associated virus (AAV) capsids has previously been exploited to redirect viral tropism. Here we demonstrate that engineering of AAV capsids as scaffolds for antigen display augments antigen-specific immunogenicity. Combining antigen display with vector-mediated overexpression resulted in a single-shot prime-boost vaccine. This new class of vaccines induced immune responses significantly faster and an IgG antibody pool of higher avidity than conventional vectors, highlighting the potency of capsid modification in vaccine development.
Authors:
Jan Rybniker; Angela Nowag; Hanna Janicki; Kai Demant; Pia Hartmann; Hildegard Büning
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-03
Journal Detail:
Title:  Journal of virology     Volume:  86     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-01-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13800-4     Citation Subset:  IM    
Affiliation:
1st Department of Internal Medicine, Division of Infectious Diseases, University Hospital Cologne, Cologne, Germany.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / biosynthesis
Antigens, Viral / genetics*,  immunology
Capsid*
Dependovirus / genetics*
Genetic Vectors*
Viral Vaccines / genetics,  immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/Viral Vaccines
Comments/Corrections

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