| Incorporation of the HIV-1 microbicide cyanovirin-N in a food product. | |
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MedLine Citation:
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PMID: 21926631 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: An urgent need exists for HIV-1 microbicides. Here, we describe the in vivo testing of lactic acid bacteria bioengineered to secrete cyanovirin-N. We fed pigtail macaques a yogurt formulation that used bioengineered strains as a starter culture. Cyanovirin-N expression could be detected in the rectal vault during and immediately after feeding. Ex vivo viral challenge of rectal tissue biopsies revealed that peak viral burden was significantly lower in tissue obtained from experimental animals compared to control animals. Formulation of candidate compounds in lactic acid bacteria and their oral administration appears to be a feasible strategy for mucosal delivery of microbicides. |
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Authors:
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Ming Li; Dorothy L Patton; Yvonne Cosgrove-Sweeney; Deena Ratner; Lisa C Rohan; Alexander M Cole; Patrick M Tarwater; Phalguni Gupta; Bharat Ramratnam |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-15 |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: - ISSN: 1944-7884 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, Rhode Island and Miriam Hospitals, Warren Alpert Medical School of Brown University, Providence, RI 2Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 3Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, PA 4Magee Womens Research Institute and the Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 5Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 6Department of Biostatistics, Texas Tech University Health Sciences Center, El Paso, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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