| Incorporation of the HIV-1 microbicide cyanovirin-N in a food product. | |
| | |
MedLine Citation:
|
PMID: 21926631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An urgent need exists for HIV-1 microbicides. Here, we describe the in vivo testing of lactic acid bacteria bioengineered to secrete cyanovirin-N. We fed pigtail macaques a yogurt formulation that used bioengineered strains as a starter culture. Cyanovirin-N expression could be detected in the rectal vault during and immediately after feeding. Ex vivo viral challenge of rectal tissue biopsies revealed that peak viral burden was significantly lower in tissue obtained from experimental animals compared with control animals. Formulation of candidate compounds in lactic acid bacteria and their oral administration seems to be a feasible strategy for mucosal delivery of microbicides. |
| | |
Authors:
|
Ming Li; Dorothy L Patton; Yvonne Cosgrove-Sweeney; Deena Ratner; Lisa C Rohan; Alexander M Cole; Patrick M Tarwater; Phalguni Gupta; Bharat Ramratnam |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Journal of acquired immune deficiency syndromes (1999) Volume: 58 ISSN: 1944-7884 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-10-28 Completed Date: 2011-12-22 Revised Date: 2013-02-19 |
Medline Journal Info:
|
Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
|
Languages: eng Pagination: 379-84 Citation Subset: IM; X |
Affiliation:
|
Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, Rhode Island and Miriam Hospitals, Warren Alpert Medical School of Brown University, Providence, RI, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-HIV Agents / administration & dosage Bacterial Proteins / administration & dosage* Carrier Proteins / administration & dosage* Feces / chemistry, virology Female Food Additives / administration & dosage* HIV Infections / prevention & control HIV-1 / drug effects Macaca nemestrina Rectum / chemistry, drug effects, virology Virus Replication / drug effects Yogurt* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 AA019072/AA/NIAAA NIH HHS; P20RR025179/RR/NCRR NIH HHS; P30 AI042853/AI/NIAID NIH HHS; P30AI042853/AI/NIAID NIH HHS; RR00166/RR/NCRR NIH HHS; T32DA013911/DA/NIDA NIH HHS; U19 AI065430/AI/NIAID NIH HHS; U19AI065430/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anti-HIV Agents; 0/Bacterial Proteins; 0/Carrier Proteins; 0/Food Additives; 184539-38-6/cyanovirin N |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expectancy and readiness-based predictors of treatment uptake among the urban poor living with HIV.
Next Document: Plasma and intracellular pharmacokinetics of darunavir/ritonavir once daily and raltegravir once and...