Document Detail

Incorporation of biomarker assessment in novel clinical trial designs: personalizing brain tumor treatments.
MedLine Citation:
PMID:  21125354     Owner:  NLM     Status:  MEDLINE    
Advances in molecular genetics have aided the identification of potential biomarkers with significant clinical promise in neurooncology. These advances and the evolution of targeted therapeutics necessitate the development and incorporation of innovative clinical trial designs that can effectively validate and assess the clinical utility of biomarkers. In this article, we review the use and potential of several such designs in neurooncology trials in order to support the development of personalized treatment approaches for brain tumor patients.
Evanthia Galanis; Wenting Wu; Jann Sarkaria; Susan M Chang; Howard Colman; Daniel Sargent; David A Reardon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current oncology reports     Volume:  13     ISSN:  1534-6269     ISO Abbreviation:  Curr Oncol Rep     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-04-21     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  100888967     Medline TA:  Curr Oncol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-9     Citation Subset:  IM    
Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Antineoplastic Protocols
Brain Neoplasms / chemistry*,  genetics,  therapy*
Clinical Trials as Topic / methods*
Individualized Medicine / methods*
Molecular Biology / methods*
Research Design
Tumor Markers, Biological / analysis*
Grant Support
CA-108961/CA/NCI NIH HHS; P50 CA108961/CA/NCI NIH HHS; P50 CA108961-02/CA/NCI NIH HHS
Reg. No./Substance:
0/Tumor Markers, Biological

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