Document Detail


Incorporation of 2-fluorohistidine in murine protein in vivo.
MedLine Citation:
PMID:  1528089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tissue distribution and time course of incorporation into acid insoluble (bound) and acid soluble (free) fractions of [3H]2-fluorohistidine is compared to that of U[14C]Histidine in mouse tissues in vivo. The cycloheximide-sensitive incorporation of 2-FHis is between 9 and 17 percent of that of His. Unlike [14C]His a major fraction, approximately 90% at 72 hrs, of isotope derived from [3H]2-FHis remains in tissues for a prolonged period in an acid soluble form. The excretion of isotope derived from [14C]His (T1/2 = 5 hr) is more rapid than from [3H]2-FHis (T1/2 = 11.4 hrs). 2-FHis, at doses from 100 to 250 mg/kg produce a reversible inhibition of growth in mice.
Authors:
C R Creveling; W L Padgett; E T McNeal; L A Cohen; K L Kirk
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  51     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-20     Completed Date:  1992-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1197-204     Citation Subset:  IM    
Affiliation:
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Brain / metabolism
Carbon Radioisotopes
Cycloheximide / pharmacology
Dose-Response Relationship, Drug
Histidine / analogs & derivatives*,  metabolism,  pharmacokinetics
Kidney / metabolism
Leucine / metabolism,  pharmacokinetics
Liver / metabolism
Male
Mice
Mice, Inbred BALB C
Proteins / metabolism*
Sensitivity and Specificity
Solubility
Tissue Distribution
Tritium
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Proteins; 10028-17-8/Tritium; 57212-36-9/2-fluorohistidine; 61-90-5/Leucine; 66-81-9/Cycloheximide; 71-00-1/Histidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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