| Incorporation of 2-fluorohistidine in murine protein in vivo. | |
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MedLine Citation:
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PMID: 1528089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The tissue distribution and time course of incorporation into acid insoluble (bound) and acid soluble (free) fractions of [3H]2-fluorohistidine is compared to that of U[14C]Histidine in mouse tissues in vivo. The cycloheximide-sensitive incorporation of 2-FHis is between 9 and 17 percent of that of His. Unlike [14C]His a major fraction, approximately 90% at 72 hrs, of isotope derived from [3H]2-FHis remains in tissues for a prolonged period in an acid soluble form. The excretion of isotope derived from [14C]His (T1/2 = 5 hr) is more rapid than from [3H]2-FHis (T1/2 = 11.4 hrs). 2-FHis, at doses from 100 to 250 mg/kg produce a reversible inhibition of growth in mice. |
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Authors:
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C R Creveling; W L Padgett; E T McNeal; L A Cohen; K L Kirk |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Life sciences Volume: 51 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-10-20 Completed Date: 1992-10-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1197-204 Citation Subset: IM |
Affiliation:
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Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Brain / metabolism Carbon Radioisotopes Cycloheximide / pharmacology Dose-Response Relationship, Drug Histidine / analogs & derivatives*, metabolism, pharmacokinetics Kidney / metabolism Leucine / metabolism, pharmacokinetics Liver / metabolism Male Mice Mice, Inbred BALB C Proteins / metabolism* Sensitivity and Specificity Solubility Tissue Distribution Tritium |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Proteins; 10028-17-8/Tritium; 57212-36-9/2-fluorohistidine; 61-90-5/Leucine; 66-81-9/Cycloheximide; 71-00-1/Histidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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