Document Detail


Incorporating microorganisms into polymer layers provides bioinspired functional living materials.
MedLine Citation:
PMID:  22198770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Artificial two-dimensional biological habitats were prepared from porous polymer layers and inoculated with the fungus Penicillium roqueforti to provide a living material. Such composites of classical industrial ingredients and living microorganisms can provide a novel form of functional or smart materials with capability for evolutionary adaptation. This allows realization of most complex responses to environmental stimuli. As a conceptual design, we prepared a material surface with self-cleaning capability when subjected to standardized food spill. Fungal growth and reproduction were observed in between two specifically adapted polymer layers. Gas exchange for breathing and transport of nutrient through a nano-porous top layer allowed selective intake of food whilst limiting the microorganism to dwell exclusively in between a confined, well-enclosed area of the material. We demonstrated a design of such living materials and showed both active (eating) and waiting (dormant, hibernation) states with additional recovery for reinitiation of a new active state by observing the metabolic activity over two full nutrition cycles of the living material (active, hibernation, reactivation). This novel class of living materials can be expected to provide nonclassical solutions in consumer goods such as packaging, indoor surfaces, and in biotechnology.
Authors:
Lukas C Gerber; Fabian M Koehler; Robert N Grass; Wendelin J Stark
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-12-22
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-05     Completed Date:  2012-03-06     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-4     Citation Subset:  IM    
Affiliation:
Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, Eidgenössiche Technische Hochschule Zurich, 8093 Zurich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials / pharmacology*
Culture Media / pharmacology
Disinfection
Microbial Viability / drug effects
Microscopy, Electron, Scanning
Penicillium / drug effects,  metabolism*
Polymers / chemistry*
Porosity / drug effects
Surface Properties / drug effects
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Culture Media; 0/Polymers
Comments/Corrections

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