Document Detail

Inconsistent reactivity of an anti-sperm monoclonal antibody and its relationship to sperm capacitation.
MedLine Citation:
PMID:  2431138     Owner:  NLM     Status:  MEDLINE    
An anti-sperm monoclonal antibody was developed from female C57BL/6 mice immunized with epididymal sperm from a syngeneic male mouse. Immunofluorescence staining revealed that the antibody did not react to fresh epididymal sperm but attached to the capacitated sperm found in the peri-vitelline spaces of the ova. When the antibody was applied to sperm incubated in vitro, variously stained sperm were observed. It was presumed that the antigenic site detected by the antibody was hidden in the fresh epididymal sperm and was spread from the acrosomal cap region to the entire head during the capacitation process.
M Okabe; K Takada; T Adachi; Y Kohama; T Mimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  9     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1987-01-02     Completed Date:  1987-01-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal / diagnostic use*,  immunology
Epididymis / cytology
Epitopes / immunology
Fluorescent Antibody Technique
Mice, Inbred Strains
Sperm Capacitation*
Spermatozoa / immunology*
Reg. No./Substance:
0/Antibodies; 0/Antibodies, Monoclonal; 0/Epitopes

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