Document Detail


Inconsistent effects of iron-folic acid and/or zinc supplementation on the cognitive development of infants.
MedLine Citation:
PMID:  22283033     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite concerns over the neurocognitive effects of micronutrient deficiencies in infancy, few studies have examined the effects of micronutrient supplementation on specific cognitive indicators. This study investigated, in 2002, the effects of iron-folic acid and/or zinc supplementation on the results of Fagan Test of Infant Intelligence (FTII) and the A-not-B Task of executive functioning among 367 Nepali infants living in Sarlahi district. Infants were enrolled in a cluster-randomized, placebo-controlled clinical trial of daily supplementation with 5 mg of zinc, 6.25 mg of iron with 25 microg of folic acid, or zinc-iron-folic acid, or placebo. These were tested on both the tasks using five indicators of information processing: preference for novelty (FTII), fixation duration (FTII), accelerated performance (> or = 85% correct; A-not-B), deteriorated performance (< 75% correct and > 1 error on repeat-following-correct trails; A-not-B), and the A-not-B error (A-not-B). At 39 and 52 weeks, 247 and 333 infants respectively attempted the cognitive tests; 213 made an attempt to solve both the tests. The likelihood of females completing the A-not-B Task was lower compared to males when cluster randomization was controlled [odds ratio = 0.67; 95% confidence interval 0.46-0.97; p < 0.05]. All of the five cognitive outcomes were modelled in linear and logistic regression. The results were not consistent across either the testing sessions or the information-processing indicators. Neither the combined nor the individual micronutrient supplements improved the performance on the FTII or the A-not-B Task (p > 0.05). These findings suggest that broader interventions (both in terms of scope and duration) are needed for infants who face many biological and social stressors.
Authors:
Emily H Siegel; Katarzyna Kordas; Rebecca J Stoltzfus; Joanne Katz; Subarna K Khatry; Steven C LeClerq; James M Tielsch
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of health, population, and nutrition     Volume:  29     ISSN:  1606-0997     ISO Abbreviation:  J Health Popul Nutr     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-02-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100959228     Medline TA:  J Health Popul Nutr     Country:  Bangladesh    
Other Details:
Languages:  eng     Pagination:  593-604     Citation Subset:  IM    
Affiliation:
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. SiegelEH@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Child Development / physiology*
Cluster Analysis
Cognition / physiology*
Dietary Supplements*
Female
Folic Acid / pharmacology*
Humans
Infant
Iron / pharmacology*
Male
Nepal
Neuropsychological Tests / statistics & numerical data
Odds Ratio
Rural Population
Sex Distribution
Zinc / pharmacology*
Grant Support
ID/Acronym/Agency:
HD 38753/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
59-30-3/Folic Acid; 7439-89-6/Iron; 7440-66-6/Zinc
Comments/Corrections

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