Document Detail

Incongruent cerebral growth in sudden infant death syndrome.
MedLine Citation:
PMID:  15832619     Owner:  NLM     Status:  MEDLINE    
Sudden infant death syndrome remains a leading cause of post-neonatal mortality in developed countries. Its etiopathogenic mechanisms are unknown. In this neuropathologic study, we noticed that the weights of the brains of infants who died from sudden infant death syndrome (n = 97) were invariably heavier in comparison with those of a group of age-matched controls (n = 23) issuing from the same local population. Brain edema was not a major element, and there were no significant microscopic or macroscopic cerebral anomalies in the brains from either of the study groups. Head circumference did not show a parallel increase in infants with sudden infant death syndrome. The excessive brain weight might reflect abnormal cerebral development and could be detrimental to vital neural control. In a previous study, we disclosed cytokine overexpression in the brains of these victims. Whether increased brain weight is linked to cytokine up-regulation remains, however, a moot case and merits further exploration.
Hazim Kadhim; Guillaume Sébire; Monia Khalifa; Philippe Evrard; José Groswasser; Patricia Franco; André Kahn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of child neurology     Volume:  20     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-04-18     Completed Date:  2005-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  244-6     Citation Subset:  IM    
Anatomic Pathology Service, Brugmann University Hospital, Brussels, Belgium.
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MeSH Terms
Brain / growth & development*,  pathology*
Case-Control Studies
Organ Size
Risk Factors
Sudden Infant Death / etiology,  pathology*

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