Document Detail

Incomplete palmitate oxidation. Possible source of human myopathy.
MedLine Citation:
PMID:  7115144     Owner:  NLM     Status:  MEDLINE    
A study of palmitate oxidation in 200 consecutive human muscle biopsy specimens showed 14 patients in whom there was abnormal, incomplete palmitate oxidation when the rate of oxidation of palmitate 14C (ul) was compared with that of palmitate 14C (at carbon 1). Five patients had denervation as a primary diagnosis, and the remaining nine had a primary muscle disease. Of this latter group, six had clinical similarities, including proximal weakness, necrotic fibers on muscle biopsy, and extreme elevations of serum creatine kinase. With one exception, lipid storage was not part of the syndrome. The possibility of incomplete palmitate oxidation due to a defect in beta-oxidation producing a human myopathy is discussed.
J B Shumate; M H Brooke; J E Carroll; R M Choksi
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of neurology     Volume:  39     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  561-4     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Middle Aged
Muscular Diseases / etiology*,  metabolism,  pathology
Palmitates / metabolism*
Palmitic Acids / metabolism*
Reg. No./Substance:
0/Palmitates; 0/Palmitic Acids

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