| Incomplete cellular depopulation may explain the high failure rate of bovine ureteric grafts. | |
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MedLine Citation:
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PMID: 18344206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim was to assess the results of a decellularized bovine ureter graft (SynerGraft) for complex venous access. METHODS: Bovine ureter conduits were implanted in patients with a failed fistula or access graft in whom native vessels were unsuitable as conduits. Graft histories were obtained from all patients who had undergone this procedure at one institution. Failed grafts were explanted and subjected to histological examination. A sample of fresh bovine ureter was immunostained for galactose (alpha1 --> 3) galactose (alpha-Gal). RESULTS: Nine patients with a median age of 46 (range 25-70) years underwent complex venous access surgery between August 2004 and November 2006 using a SynerGraft. Graft types included loop superficial femoral artery to stump of long saphenous vein (four patients), loop brachial artery to vein (two), brachial artery to axillary vein (two) and left axillary artery to innominate vein (one). Three grafts developed aneurysmal dilatation and two thrombosed. Histological assessment of the explanted bovine ureters revealed acute and chronic transmural inflammation. Immunostaining of fresh bovine ureter suggested residual cells and the xenoantigen alpha-Gal. CONCLUSION: Graft failure with aneurysmal dilatation and thrombosis in complex arteriovenous conduits using bovine ureter may be due to residual xenoantigens. |
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Authors:
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J I Spark; S Yeluri; C Derham; Y T Wong; D Leitch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of surgery Volume: 95 ISSN: 1365-2168 ISO Abbreviation: Br J Surg Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-14 Completed Date: 2008-05-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: England |
Other Details:
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Languages: eng Pagination: 582-5 Citation Subset: AIM; IM |
Copyright Information:
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2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK. jamesianspark@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Antigens, Heterophile / metabolism Catheters, Indwelling Cattle Equipment Failure Female Graft Occlusion, Vascular / immunology, pathology Graft Rejection / immunology, pathology* Humans Male Middle Aged Thrombectomy / methods Thrombosis / pathology Transplantation Immunology Transplantation, Heterologous Uterus / immunology, pathology, transplantation* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Heterophile |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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