Document Detail

Incomplete cellular depopulation may explain the high failure rate of bovine ureteric grafts.
MedLine Citation:
PMID:  18344206     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim was to assess the results of a decellularized bovine ureter graft (SynerGraft) for complex venous access. METHODS: Bovine ureter conduits were implanted in patients with a failed fistula or access graft in whom native vessels were unsuitable as conduits. Graft histories were obtained from all patients who had undergone this procedure at one institution. Failed grafts were explanted and subjected to histological examination. A sample of fresh bovine ureter was immunostained for galactose (alpha1 --> 3) galactose (alpha-Gal). RESULTS: Nine patients with a median age of 46 (range 25-70) years underwent complex venous access surgery between August 2004 and November 2006 using a SynerGraft. Graft types included loop superficial femoral artery to stump of long saphenous vein (four patients), loop brachial artery to vein (two), brachial artery to axillary vein (two) and left axillary artery to innominate vein (one). Three grafts developed aneurysmal dilatation and two thrombosed. Histological assessment of the explanted bovine ureters revealed acute and chronic transmural inflammation. Immunostaining of fresh bovine ureter suggested residual cells and the xenoantigen alpha-Gal. CONCLUSION: Graft failure with aneurysmal dilatation and thrombosis in complex arteriovenous conduits using bovine ureter may be due to residual xenoantigens.
J I Spark; S Yeluri; C Derham; Y T Wong; D Leitch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  95     ISSN:  1365-2168     ISO Abbreviation:  Br J Surg     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  582-5     Citation Subset:  AIM; IM    
Copyright Information:
2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK.
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MeSH Terms
Antigens, Heterophile / metabolism
Catheters, Indwelling
Equipment Failure
Graft Occlusion, Vascular / immunology,  pathology
Graft Rejection / immunology,  pathology*
Middle Aged
Thrombectomy / methods
Thrombosis / pathology
Transplantation Immunology
Transplantation, Heterologous
Uterus / immunology,  pathology,  transplantation*
Reg. No./Substance:
0/Antigens, Heterophile

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