| Incomplete Recovery of Lumbar Intervertebral Discs 2-Years After 60-Days Bed-Rest. | |
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MedLine Citation:
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PMID: 21971124 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: Study Design. Prospective longitudinal studyObjective. To evaluate the recovery of the lumbar intervertebral discs after bed-restSummary of Background Data. Prolonged bed-rest is a useful model to understand the modelling and re-modelling of tissues due to disuse and re-loading, yet this process in the lumbar interverterbal discs has not been examined in detail.Methods. 24 male subjects completed 60 days of head-down tilt bed-rest as part of the 2 Berlin BedRest Study (BBR2-2), and returned for magnetic resonance (MR) scanning 180 days (n = 22) and 2 years (n = 21) after bed-rest. Lumbar disc volume, anterior and posterior disc height, disc signal intensity, intervertebral length and lordosis were measured on sagittal plane MR-images.Results. Compared to prior to bed-rest, increases in disc volume, disc height and intervertebral length persisted 180 days (p≤0.0004) and 720 days (p≤0.024) after bed-rest. Disc signal intensity remained increased 180 days (p = 0.034) after bed-rest but was then decreased (p = 0.018) compared to baseline at the next measurement date.Conclusion. The recovery of the lumbar intervertebral discs after 60-days bed-rest is a prolonged process and incomplete within 2 years. |
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Authors:
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Daniel L Belavý; Gabriele Armbrecht; Dieter Felsenberg |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-30 |
Journal Detail:
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Title: Spine Volume: - ISSN: 1528-1159 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Charité Universitätsmedizin Berlin, Zentrum für Muskel- und Knochenforschung, Hindenburgdamm 30, D-12200 Berlin, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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