| Incommensurate oxygen consumption in response to maximal oxygen availability predicts postinjury multiple organ failure. | |
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MedLine Citation:
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PMID: 1344026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Untreated flow-dependent oxygen consumption (VO2) has recently been implicated as an unrecognized risk factor for multiple organ failure (MOF). We therefore prospectively studied 39 severely injured patients with known risk factors for multiple organ failure who were subjected to an established resuscitation protocol aimed at maximizing oxygen delivery (DO2 greater than 600 mL/min.m2) to attain a VO2 goal of greater than 150 mL/min.m2. Fifteen (38%) of these high risk patients did not meet this VO2 goal by 12 hours. These nonresponding patients had significantly elevated lactate levels, suggesting defective aerobic metabolism. Of note, this blunted VO2 response despite maximal efforts to enhance peripheral oxygen availability predicted MOF. These data serve to re-emphasize the importance of the initial shock insult in causing or priming the host for the development of late MOF. |
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Authors:
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F A Moore; J B Haenel; E E Moore; T A Whitehill |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 33 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-08-25 Completed Date: 1992-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 58-65; discussion 65-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Denver General Hospital, CO 80204-4507. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Hemodynamics Humans Injury Severity Score Male Middle Aged Multiple Organ Failure / etiology* Oxygen Consumption* Prospective Studies Resuscitation Risk Factors Wounds and Injuries / complications*, metabolism |
| Comments/Corrections | |
Comment In:
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J Trauma. 1993 Dec;35(6):968-9
[PMID:
8264005
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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