| Inclusion complex formation of steroidal drugs with hydroxypropyl-beta-cyclodextrin studied by charge-transfer chromatography. | |
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MedLine Citation:
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PMID: 9863956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interaction between 17 steroidal drugs and hyroxypropyl-beta-cyclodextrin (HPbetaBCD) was determined by charge-transfer chromatography and the relative strength of interaction was calculated. HPbetaCD interacted with each steroidal drugs decreasing the hydrophobicity of the guest molecules. The relative strength of interaction considerably depended on the structure of the drug molecule. Hydrophobicity parameters of drugs significantly influenced the strength of interaction indicating the involvement of hydrophobic forces in the binding of drugs to HPbetaCD. The marked influence of HPbetaCD on the hydrophobicity of drugs suggests that this interaction may modify the biological properties (adsorption, uptake, half-life etc.) of drug-HPbetaCD complexes drug resulting in modified efficacy. |
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Authors:
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T Cserháti; E Forgács |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 18 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-04-07 Completed Date: 1999-04-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 179-85 Citation Subset: IM |
Affiliation:
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Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography Cyclodextrins / chemistry* Molecular Structure Solubility Steroids / chemistry* beta-Cyclodextrins* |
| Chemical | |
Reg. No./Substance:
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0/Cyclodextrins; 0/Steroids; 0/beta-Cyclodextrins; 94035-02-6/2-hydroxypropyl-beta-cyclodextrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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