Document Detail


Inclusion of pediatric samples in an opt-out biorepository linking DNA to de-identified medical records: pediatric BioVU.
MedLine Citation:
PMID:  23281421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Vanderbilt DNA repository, BioVU, links DNA from leftover clinical blood samples to de-identified electronic medical records (EMRs). After initiating adult sample collection, pediatric extension required consideration of ethical concerns specific to pediatrics and implementation of specialized DNA extraction methods. In the first year of pediatric sample collection, more than 11,000 samples from individuals younger than 18 years were included. We compared data from the pediatric BioVU cohort with those from the overall Vanderbilt University Medical Center pediatric population and found similar demographic characteristics; however, the BioVU cohort had higher rates of select diseases, medication exposures, and laboratory testing, demonstrating enriched representation of severe or chronic disease. The fact that the sample accumulation is not balanced may accelerate research in some cohorts while limiting the study of relatively benign conditions and the accrual of unaffected and unbiased control samples. BioVU represents a feasible model for pediatric DNA biobanking but involves both ethical and practical considerations specific to the pediatric population.
Authors:
T L McGregor; S L Van Driest; K B Brothers; E A Bowton; L J Muglia; D M Roden
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-21
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  93     ISSN:  1532-6535     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-02-26     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  204-11     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Specimen Banks / ethics*,  standards
Biomedical Research / ethics*,  standards
Child
Child, Preschool
DNA / blood*
Databases, Nucleic Acid / ethics*,  standards
Electronic Health Records / ethics*,  standards
Humans
Infant
Informed Consent
Young Adult
Grant Support
ID/Acronym/Agency:
5T32 GM007569-33/GM/NIGMS NIH HHS; 5U01HG004603/HG/NHGRI NIH HHS; K12 ES015855/ES/NIEHS NIH HHS; K12 ES015855/ES/NIEHS NIH HHS; S10 RR027764/RR/NCRR NIH HHS; S10 RR027764/RR/NCRR NIH HHS; T32 GM007569/GM/NIGMS NIH HHS; U01 HG004603/HG/NHGRI NIH HHS; U01 HG006378/HG/NHGRI NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 RR024975/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9007-49-2/DNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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