| Inclusion of pediatric samples in an opt-out biorepository linking DNA to de-identified medical records: pediatric BioVU. | |
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MedLine Citation:
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PMID: 23281421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Vanderbilt DNA repository, BioVU, links DNA from leftover clinical blood samples to de-identified electronic medical records (EMRs). After initiating adult sample collection, pediatric extension required consideration of ethical concerns specific to pediatrics and implementation of specialized DNA extraction methods. In the first year of pediatric sample collection, more than 11,000 samples from individuals younger than 18 years were included. We compared data from the pediatric BioVU cohort with those from the overall Vanderbilt University Medical Center pediatric population and found similar demographic characteristics; however, the BioVU cohort had higher rates of select diseases, medication exposures, and laboratory testing, demonstrating enriched representation of severe or chronic disease. The fact that the sample accumulation is not balanced may accelerate research in some cohorts while limiting the study of relatively benign conditions and the accrual of unaffected and unbiased control samples. BioVU represents a feasible model for pediatric DNA biobanking but involves both ethical and practical considerations specific to the pediatric population. |
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Authors:
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T L McGregor; S L Van Driest; K B Brothers; E A Bowton; L J Muglia; D M Roden |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-11-21 |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 93 ISSN: 1532-6535 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-22 Completed Date: 2013-02-26 Revised Date: 2013-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 204-11 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Vanderbilt University and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Specimen Banks / ethics*, standards Biomedical Research / ethics*, standards Child Child, Preschool DNA / blood* Databases, Nucleic Acid / ethics*, standards Electronic Health Records / ethics*, standards Humans Infant Informed Consent Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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5T32 GM007569-33/GM/NIGMS NIH HHS; 5U01HG004603/HG/NHGRI NIH HHS; K12 ES015855/ES/NIEHS NIH HHS; K12 ES015855/ES/NIEHS NIH HHS; S10 RR027764/RR/NCRR NIH HHS; S10 RR027764/RR/NCRR NIH HHS; T32 GM007569/GM/NIGMS NIH HHS; U01 HG004603/HG/NHGRI NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 RR024975/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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