Document Detail

Inclusion of Atlantic salmon in the Chinese diet reduces cardiovascular disease risk markers in dyslipidemic adult men.
MedLine Citation:
PMID:  20797476     Owner:  NLM     Status:  MEDLINE    
Although the beneficial effects of n-3 fatty acids on several physiologic functions have been widely reported, information about the effects of oily fish in the Asian diet on cardiovascular disease (CVD) risk is diminutive. We hypothesize that daily inclusion of oily fish for 8 weeks in the Chinese diet will elevate serum eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels and reduce CVD risk markers in dyslipidemic adult men, comparable with the effects generally observed by inclusion of oily fish in the Western diet. In this 8-week randomized, parallel-arm, food-based intervention study, lunches were prepared with 500 g pork/chicken/beef, typically consumed fish (hairtail and freshwater carp), or oily fish (salmon). Male subjects aged between 35 and 70 years with hyperlipidemia were randomly assigned to eat lunches with pork/chicken/beef (n = 30 subjects at 8 weeks), freshwater fish (n = 30), or oily fish (n = 32). Circulating markers were measured at baseline and at 8 weeks. In the oily fish diet, dietary EPA and DHA levels were significantly increased as compared with other diets; and the n-6:n-3 polyunsaturated fatty acid ratio was decreased (P < .05). Thus, the oily fish diet significantly elevated serum EPA and DHA concentrations (P < .01) and lowered serum n-6:n-3 ratio at 8 weeks (P < .05). Furthermore, oily fish intake significantly reduced serum levels of triglycerides (P < .05) and interleukin-6 (P < .01) and increased levels of high-density lipoprotein cholesterol (P < .01). In conclusion, daily inclusion of oily fish as part of the Chinese diet for 8 weeks is sufficient to significantly increase the serum content of long-chain n-3 polyunsaturated fatty acids and reduce levels of CVD risk markers in dyslipidemic adult men.
Jian Zhang; Chunrong Wang; Lixiang Li; Qingqing Man; Pengkun Song; Liping Meng; Zhen-Yu Du; Livar Frøyland
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition research (New York, N.Y.)     Volume:  30     ISSN:  1879-0739     ISO Abbreviation:  Nutr Res     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8303331     Medline TA:  Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-54     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China.
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MeSH Terms
Biological Markers / blood*
Cardiovascular Diseases / prevention & control*
Cholesterol, HDL / blood
Docosahexaenoic Acids / blood
Eicosapentaenoic Acid / blood
Fatty Acids / blood
Fatty Acids, Omega-3 / administration & dosage,  blood
Hyperlipidemias / blood,  complications,  diet therapy*
Interleukin-6 / blood
Middle Aged
Risk Factors
Triglycerides / blood
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Interleukin-6; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids

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