| Inclusion of 10% fish oil in mixed medium-chain triacylglycerol-long-chain triacylglycerol emulsions increases plasma triacylglycerol clearance and induces rapid eicosapentaenoic acid (20:5n-3) incorporation into blood cell phospholipids. | |
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MedLine Citation:
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PMID: 18689362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Lipolysis of a fish oil (FO) emulsion is much slower than that of a soybean [long-chain triacylglycerol (LCT)] emulsion; in contrast, emulsions containing medium-chain triacylglycerol (MCT) are efficiently hydrolyzed by lipoprotein lipase. OBJECTIVES: We questioned whether incorporating 10% FO in a mixed MCT-LCT emulsion would affect plasma triacylglycerol clearance and provide efficient delivery of n-3 polyunsaturated fatty acids to cells and tissues. DESIGN: This prospective crossover study was conducted in 8 normolipidemic subjects with the use of the hypertriglyceridemic clamp model and compared plasma triacylglycerol clearance of a lipid emulsion (5:4:1) made of 50% MCT, 40% LCT, and 10% FO (wt:wt:wt) to a control (5:5) preparation with 50% MCT and 50% LCT. Subjects were daily infused for 5 h, over 4 consecutive days. Fatty acyl pattern was daily measured in plasma phospholipids as well as in leukocyte and platelet phospholipids. RESULTS: Inclusion of 10% FO in mixed emulsion particles enhanced plasma clearance of infused triacylglycerols (18%; P < 0.0001). The faster elimination of the 5:4:1 emulsion appears related to an enhanced uptake of remnant particles rather than to faster intravascular lipolysis. Each infusion of 5:4:1 raised the eicosapentaenoic acid (C20:5n-3) concentration in blood cell phospholipids to reach a 7-fold enrichment in platelets and a >2-fold enrichment in leukocytes after 4 infusions. In contrast, the docosahexaenoic acid (C22:6n-3) concentration remained unchanged in blood cell phospholipids. CONCLUSIONS: Infusion of a mixed emulsion with MCTs, soy LCTs, and FO is associated with efficient plasma triacylglycerol clearance and results in rapid incorporation of C20:5n-3 but not C22:6n-3 in leukocyte and platelet phospholipids. |
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Authors:
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Christian M Simoens; Richard J Deckelbaum; Jacques J Massaut; Yvon A Carpentier |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 88 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-09-12 Revised Date: 2009-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 282-8 Citation Subset: AIM; IM |
Affiliation:
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L Deloyers Laboratory for Experimental Surgery, Université Libre de Bruxelles, Brussels, Belgium and the Intensive Care Unit, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Platelets / chemistry, metabolism Cross-Over Studies Dose-Response Relationship, Drug Eicosapentaenoic Acid / metabolism* Fat Emulsions, Intravenous* / chemistry Fish Oils / administration & dosage* Humans Leukocytes / chemistry, metabolism Liver / metabolism Male Metabolic Clearance Rate Parenteral Nutrition Phospholipids / chemistry, metabolism* Prospective Studies Triglycerides / blood, metabolism, pharmacokinetics* |
| Grant Support | |
ID/Acronym/Agency:
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HL40404/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 0/Fish Oils; 0/Phospholipids; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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