Document Detail


Incidentally simultaneous occurrence of RET/PTC, H4-PTEN and BRAF mutation in papillary thyroid carcinoma.
MedLine Citation:
PMID:  18226854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because interaction existed between PTEN and RET-RAS-RAF-MAPK pathway, H4-PTEN (a newly identified gene rearrangement), RET/PTC and BRAF mutation were scanned in 125 Chinese patients with papillary thyroid carcinoma (PTC). H4-PTEN were detected in 9.6% of PTC and the frequency of the occurrence of BRAF mutation and/or RET/PTC in H4-PTEN positive tumors was extremely high (75%). On the other hand, age has an important effect on the aberration formation and young age renders more prone to multi-genetic events. A combinational scanning of these involved changes will improve the predictive value of molecular aberrations in the treatment of PTC.
Authors:
Yu-Long Wang; Jiu-Cun Wang; Yi Wu; Ling Zhang; Cai-Ping Huang; Qiang Shen; Yong-Xue Zhu; Duan-Shu Li; Qing-Hai Ji
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-28
Journal Detail:
Title:  Cancer letters     Volume:  263     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-06-05     Revised Date:  2012-06-21    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  44-52     Citation Subset:  IM    
Affiliation:
Department of Head & Neck Surgery, Cancer Hospital, Fudan University, 270 Dong'an Road, Shanghai 200032, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cytoskeletal Proteins / genetics*
Female
Gene Rearrangement
Humans
Male
Middle Aged
Mutation*
PTEN Phosphohydrolase / genetics*
Proto-Oncogene Proteins B-raf / genetics*
Proto-Oncogene Proteins c-ret / genetics*
Thyroid Neoplasms / genetics*
Chemical
Reg. No./Substance:
0/CCDC6 protein, human; 0/Cytoskeletal Proteins; EC 2.7.10.1/Proto-Oncogene Proteins c-ret; EC 2.7.10.1/RET protein, human; EC 2.7.11.1/BRAF protein, human; EC 2.7.11.1/Proto-Oncogene Proteins B-raf; EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN Phosphohydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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