| Incidentally simultaneous occurrence of RET/PTC, H4-PTEN and BRAF mutation in papillary thyroid carcinoma. | |
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MedLine Citation:
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PMID: 18226854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because interaction existed between PTEN and RET-RAS-RAF-MAPK pathway, H4-PTEN (a newly identified gene rearrangement), RET/PTC and BRAF mutation were scanned in 125 Chinese patients with papillary thyroid carcinoma (PTC). H4-PTEN were detected in 9.6% of PTC and the frequency of the occurrence of BRAF mutation and/or RET/PTC in H4-PTEN positive tumors was extremely high (75%). On the other hand, age has an important effect on the aberration formation and young age renders more prone to multi-genetic events. A combinational scanning of these involved changes will improve the predictive value of molecular aberrations in the treatment of PTC. |
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Authors:
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Yu-Long Wang; Jiu-Cun Wang; Yi Wu; Ling Zhang; Cai-Ping Huang; Qiang Shen; Yong-Xue Zhu; Duan-Shu Li; Qing-Hai Ji |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-28 |
Journal Detail:
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Title: Cancer letters Volume: 263 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-03-31 Completed Date: 2008-06-05 Revised Date: 2012-06-21 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 44-52 Citation Subset: IM |
Affiliation:
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Department of Head & Neck Surgery, Cancer Hospital, Fudan University, 270 Dong'an Road, Shanghai 200032, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cytoskeletal Proteins / genetics* Female Gene Rearrangement Humans Male Middle Aged Mutation* PTEN Phosphohydrolase / genetics* Proto-Oncogene Proteins B-raf / genetics* Proto-Oncogene Proteins c-ret / genetics* Thyroid Neoplasms / genetics* |
| Chemical | |
Reg. No./Substance:
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0/CCDC6 protein, human; 0/Cytoskeletal Proteins; EC 2.7.10.1/Proto-Oncogene Proteins c-ret; EC 2.7.10.1/RET protein, human; EC 2.7.11.1/BRAF protein, human; EC 2.7.11.1/Proto-Oncogene Proteins B-raf; EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN Phosphohydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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