Document Detail

Incidentally detected liver metastasis of well-differentiated follicular carcinoma of the thyroid, mimicking ectopic thyroid.
MedLine Citation:
PMID:  10886730     Owner:  NLM     Status:  MEDLINE    
A case of incidentally detected liver metastasis of follicular carcinoma of the thyroid, histologically mimicking ectopic thyroid, is described. The patient was a 48-year-old woman. A 2-cm mass was incidentally detected in the left lobe of the liver by abdominal computed tomography (CT) scan. Partial liver resection was performed for diagnosis and treatment. Histologically, the liver nodule was composed of small-to-large follicles containing colloid material. The lining epithelium was flat or cuboidal and showed no cellular or nuclear atypia. Immunohistochemical studies for thyroid-specific proteins, thyroglobulin (Tg), triiodothyronine (T3) and thyroxine (T4), suggested that the nodule was of thyroid origin. Therefore, a differential diagnosis of metastasis of well-differentiated thyroid cancer, ectopic thyroid tissue and teratoma was made. The patient had a history of subtotal thyroidectomy performed 8 years ago due to a thyroid tumor. The original surgical specimens of the thyroid tumor were diagnosed as follicular adenoma. Additional sections of the specimen were reviewed and an area of convincing vascular invasion was found that was suggestive of follicular carcinoma. Subsequent whole-body examination failed to find other metastases. It was determined that the liver tumor was metastasized from well-differentiated follicular carcinoma of the thyroid.
T Kondo; R Katoh; K Omata; T Oyama; A Yagawa; A Kawaoi
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  50     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-08     Completed Date:  2000-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  IM    
Department of Pathology, Yamanashi Medical University, Tamaho, Japan.
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MeSH Terms
Adenocarcinoma, Follicular / metabolism,  pathology*
Cell Differentiation
Choristoma / pathology*
Diagnosis, Differential
Liver Neoplasms / metabolism,  secondary*
Middle Aged
Thyroglobulin / analysis
Thyroid Gland*
Thyroid Neoplasms / metabolism,  pathology*
Thyroxine / analysis
Triiodothyronine / analysis
Reg. No./Substance:
6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9010-34-8/Thyroglobulin

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