Document Detail


Incidental pituitary macroadenoma: a population-based study.
MedLine Citation:
PMID:  9365329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiologic analysis of incidental macroadenoma is limited to autopsy studies and case series. There are no published data about prevalence of incidental pituitary macroadenoma in living patients. The objective of this study was to determine the prevalence of incidental pituitary macroadenoma. It was designed as an observational study of cranial computed tomography reports. An urban department of veterans affairs medical center was used for the setting. The subject group consisted of 3,550 consecutive patients at the Cleveland Department of Veterans Affairs Medical Center from January 1993 to January 1996. Patients with known or suspected pituitary or parasellar disease were excluded. Cranial computed tomography reports were reviewed. Original films and medical charts of all patients with pituitary macroadenoma were reviewed. Seven patients with incidentally discovered pituitary macroadenoma that ranged from 1 cm to 2.5 cm were found; prevalence was 0.20% (95% confidence interval 0.05, 0.35%). Evidence of partial hypopituitarism was found in most patients. All patients had normal visual fields at initial examination despite the size of the tumor, but 1 of 4 had a field cut demonstrated by Goldmann perimetry. These data confirm that, although the prevalence of incidental pituitary macroadenoma is low, screening identified patients to detect deficiency of corticotropin, thyroid-stimulating hormone, and gonadotropins and to detect visual field defects is important.
Authors:
G M Nammour; J Ybarra; M H Naheedy; J H Romeo; D C Aron
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  314     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-09     Completed Date:  1997-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / complications,  epidemiology*,  radiography
Adult
Aged
Aged, 80 and over
Female
Hospitals, Veterans
Humans
Hypopituitarism / complications
Male
Middle Aged
Ohio / epidemiology
Pituitary Neoplasms / complications,  epidemiology*,  radiography
Prevalence
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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