| Incidental pituicytoma after accidental head trauma--case report and review of literature. | |
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MedLine Citation:
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PMID: 20423685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We report on a patient with pituicytoma, i.e. a rare neoplasm of the neurohypophysis, with unusual anamnestic manifestation. CASE MATERIAL: After a car accident, the patient suffered from severe persisting headaches. Diagnostic procedures revealed a minor visual impairment and restriction of the gonado- and somatotropic pituitary axis. MRI showed an architecturally solid, well demarcated and homogenous suprasellar lesion. Due to the challenging location of the lesion with a small intrasellar mass and larger suprasellar part within the hypophyseal stalk, a subtotal resection was carried out to save the pituitary function and for neuropathological assessment comprising numerous stainings and immunohistochemical reactions. We observed a highly differentiated, low proliferative, rather cellular and in individual parts moderately pleomorphic tumor with cells arranged in storiform or whorled patterns, that strongly expressed S-100 protein, microtubulus-associated protein 2 (MAP2) and vimentin. Postoperative visual field testing was inconspicuous, but pituitary malfunction was persistent. With respect to the accidental discovery of this pituicytoma, it remains unresolved whether the persisting headache was due solely to the head trauma or was additive with the effects of the pituicytoma. CONCLUSION: To date less than 30 bona fide examples have been described and typically present symptoms due to mass effects such as visual disturbances, hypopituitarism as well as interference with hypothalamic dopamine release, resulting in subsequent hyperprolactinemia accompanied by decreased libido and amenorrhea in females. These neoplasms represent an important differential diagnosis with respect to suprasellar lesions and a clinical and neuropathological challenge. |
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Authors:
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A Grote; A Kovacs; H Clusmann; A J Becker; P Niehusmann |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical neuropathology Volume: 29 ISSN: 0722-5091 ISO Abbreviation: Clin. Neuropathol. Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2011-09-14 Revised Date: 2012-09-10 |
Medline Journal Info:
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Nlm Unique ID: 8214420 Medline TA: Clin Neuropathol Country: Germany |
Other Details:
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Languages: eng Pagination: 127-33 Citation Subset: IM |
Affiliation:
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Departments of 1Neurosurgery, 2Radiology/FU Neuroradiology, and 3Neuropathology, University of Bonn Medical Center, Bonn, Germany. alexander.grote@ukb.uni-bonn.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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complications*,
pathology* Biopsy Craniocerebral Trauma / complications* Humans Incidental Findings Magnetic Resonance Imaging Male Middle Aged Pituitary Neoplasms / complications*, pathology* |
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