| Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. | |
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MedLine Citation:
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PMID: 20736774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Choriocarcinoma is frequently preceded by a complete mole, ectopic pregnancy, nonmolar intrauterine abortion, and uncommonly by a partial mole. Choriocarcinoma coexisting with or after an otherwise "normal" pregnancy is extremely rare, with an estimated occurrence of 1 per 160,000 pregnancies. We here report a case of a placental choriocarcinoma with no metastases in a full-term intrauterine pregnancy. The patient is a 29-year-old gravida 2 para 1 female, who had an uncomplicated full-term vaginal delivery of a healthy 3030 g female infant. Her current pregnancy was uneventful, and past medical history was significant for an elective termination of pregnancy 2 years ago at 8 weeks of gestation. Routine examination of the placenta showed a gray-tan nodule, measuring 2 cm in the largest dimension, with a papillary cut surface. Microscopically, this nodule was composed of highly atypical cytotrophoblastic cells and multinucleated atypical syncytiotrophoblastic cells, which were positive for beta-human chorionic gonadotrophin by immunostaining. Extensive necrosis and multiple foci of hemorrhage were present. The overall morphologic and immunohistochemical features were diagnostic for choriocarcinoma. Further investigations, including a full body computed tomography scan, showed no lesions suspicious for metastases. The patient is currently asymptomatic and being followed-up with monthly beta-human chorionic gonadotrophin levels, the most recent one being negative. By reporting this case and reviewing the literature, we support the opinion of a recent similar case report that the incidence of placental choriocarcinoma may actually be higher than expected, as placental examination after a normal spontaneous delivery is not routinely performed at most of the institutions. |
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Authors:
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Karthik A Ganapathi; Tamera Paczos; Mary D George; Samuel Goodloe; Lucia L Balos; Frank Chen |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists Volume: 29 ISSN: 1538-7151 ISO Abbreviation: Int. J. Gynecol. Pathol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-12-10 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8214845 Medline TA: Int J Gynecol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 476-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, NY 14203, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Choriocarcinoma / metabolism, pathology* Female Humans Immunohistochemistry Incidental Findings Pregnancy Term Birth Uterine Neoplasms / metabolism, pathology* |
| Comments/Corrections | |
Comment In:
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Int J Gynecol Pathol. 2011 Jul;30(4):364-5
[PMID:
21623208
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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