Document Detail

Incident major depression does not affect neuropsychological functioning in HIV-infected men.
MedLine Citation:
PMID:  17166298     Owner:  NLM     Status:  MEDLINE    
The diagnosis of lifetime major depressive disorders (MDDs) and of current major depressive episodes (MDEs) are relatively common in HIV-infected individuals, and often are assumed to influence neuropsychological (NP) performance. Although cross-sectional studies of HIV-infected individuals generally have found no systematic link between current MDE or depressive symptoms and NP performance, longitudinal studies are needed to clarify whether incident MDE may impact NP functioning in at least some cases. Two hundred twenty-seven human immunodeficiency virus (HIV)-infected adult men, who did not meet criteria for a current MDE at baseline, participated in a longitudinal NP study for an average of two years. Participants received repeated NP assessments, as well as structured psychiatric interviews to ascertain presence or absence of both lifetime MDD and current MDE. Ninety-eight participants had a lifetime history of MDD, and 23 participants met criteria for incident MDE at one of their follow-up evaluations. Groups with and without lifetime MDD and/or incident MDE had comparable demographics, HIV disease status and treatment histories at baseline, and numbers of intervening assessments between baseline and the final follow-up. Lifetime MDD was associated with greater complaints of cognitive difficulties in everyday life, and such complaints were increased at the times of incident MDE. However, detailed group comparisons revealed no NP performance differences in association with either lifetime or incident major depression. Finally, NP data from consistently nondepressed participants were used to develop "norms for change" and these findings failed to show any increased rates of NP worsening among individuals with incident MDE. Our results suggest that neurocognitive impairment and major depression should be considered as two independent processes.
Lucette A Cysique; Reena Deutsch; J Hampton Atkinson; Corinna Young; Thomas D Marcotte; Lauren Dawson; Igor Grant; Robert K Heaton;
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  13     ISSN:  1355-6177     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-14     Completed Date:  2007-03-13     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Department of Psychiatry, University of California at San Diego, San Diego, California, USA.
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MeSH Terms
Cognition Disorders / diagnosis*,  epidemiology*
Depressive Disorder, Major / diagnosis*,  epidemiology*
HIV Infections / epidemiology*
Neuropsychological Tests
Severity of Illness Index
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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