| Incidences of fatal postoperative pulmonary embolism after prophylaxis with dextran 70 and low-dose heparin: an international multicentre study. | |
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MedLine Citation:
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PMID: 7353128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A total of 4352 patients were admitted to a prospective' randomised multicentre trial comparing the prophylactic efficacy of dextran 70 and low-dose heparin against fatal pulmonary embolism after elective operations for general, orthopaedic, urological, and gynaecological conditions. Out of 3984 patients correctly admitted, 1993 were allocated to receive dextran 70 and 1991 to receive low-dose heparin. Withdrawal of prophylaxis because of bleeding or technical difficulties occurred more often in the heparin group, but allergic reactions were more common in the dextran group. Of the 75 patients who died within 30 days after operation, 38 had been given dextran and 37 low-dose heparin. Necropsy was performed in 33 and 32 of these cases respectively. In six patients in each group pulmonary embolism was the sole or a contributory cause of death. Of these, five patients in the dextran group and two in the heparin group had received a full course of prophylaxis. There was no statistically significant difference between the two treatment groups in the incidence of fatal pulmonary embolism after a full course of prophylaxis. |
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Authors:
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U F Gruber; T Saldeen; T Brokop; B Eklöf; I Eriksson; I Goldie; L Gran; M Hohl; T Jonsson; S Kristersson; K G Ljungström; T Lund; H M Moe; E Svensjö; D Thomson; J Torhorst; A Trippestad; M Ulstein |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British medical journal Volume: 280 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-04-25 Completed Date: 1980-04-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 69-72 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Dextrans / adverse effects, therapeutic use* Drug Administration Schedule Drug Hypersensitivity / etiology Female Hemorrhage / chemically induced Heparin / administration & dosage, adverse effects, therapeutic use* Humans Male Middle Aged Postoperative Complications / metabolism, prevention & control* Prospective Studies Pulmonary Embolism / metabolism, prevention & control* Random Allocation |
| Chemical | |
Reg. No./Substance:
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9004-54-0/Dextrans; 9005-49-6/Heparin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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