| Incidence of urinary tract infection in patients with type 2 diabetes. Experience from adverse event reporting in clinical trials. | |
| | |
MedLine Citation:
|
PMID: 20967764 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
PURPOSE: Diabetes mellitus has long been widely considered to be associated with an increased risk of urinary tract infection (UTI), but information on incidence rates are scarce and risk factor data have been conflicting. The aim was to estimate UTI incidence and evaluate potential risk factors for UTI in patients with type 2 diabetes included in recent clinical trials. METHODS: Type 2 diabetes patients from 10 AstraZeneca phase III diabetes clinical trials (n=6016, mean 57.4 years, 50.7% female) conducted during 2004-2007 were included. Patients free of UTI at baseline were followed for up to 6 months after inclusion in the trials. UTI was considered present if any term sorting under the MedDRA high-level term "UTIs" was recorded as an adverse event. RESULTS: In all, 142 patients had an adverse event for UTI, corresponding to an incidence of 59.5/1000 person-years for all patients (91.5/1000 in women, 28.2/1000 in men) and a cumulative incidence of 2% during 6 months. Female gender was associated with an increased incidence [relative risk (RR) 3.4; 95% confidence interval (CI) 2.3-5.1] and also higher age (RR 2.5 [95% CI 1.4-4.8] for ages ≥ 70 years vs. 40-49 years). No increased incidence was associated with body mass index (25-29, 30+ vs. <25 kg/m(2) ), HbA1c (<8% vs. >8%), race (Black, Oriental vs. Caucasian) or drug treatment (study drug, comparator vs. placebo). A history of immune system disorder conveyed a twofold higher risk for UTI. CONCLUSION: UTI is common among female patients with type 2 diabetes and older patients of both genders. |
| | |
Authors:
|
Niklas Hammar; Bahman Farahmand; Mikael Gran; Svante Joelson; Susan W Andersson |
Related Documents
:
|
17488764 - A propensity-matched study of the effect of diabetes on the natural history of heart fa... 19105914 - Preventive advice given by patients with type 2 diabetes to their offspring. 12663584 - High incidence of tacrolimus-associated posttransplantation diabetes in the korean rena... 11835694 - Prevalence and risk factors for vaginal candida colonization in women with type 1 and t... 7843524 - Latino health in los angeles: family medicine in a changing minority context. 19154414 - Prevention of proliferative changes of forestomach mucosa by blood glucose control with... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-21 |
Journal Detail:
|
Title: Pharmacoepidemiology and drug safety Volume: 19 ISSN: 1099-1557 ISO Abbreviation: Pharmacoepidemiol Drug Saf Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9208369 Medline TA: Pharmacoepidemiol Drug Saf Country: England |
Other Details:
|
Languages: eng Pagination: 1287-92 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A technique combining trifluoroacetyl derivatization and gas chromatography-mass spectrometry to dis...
Next Document: A novel high-resolution chipCE assay for rapid detection of EGFR gene mutations and amplifications i...