| Incidence of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. | |
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MedLine Citation:
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PMID: 15127914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are rare disorders characterized by platelet aggregation, microthrombi, and resulting tissue damage. We studied the incidence and possible risk factors for these diseases in 3 large populations in the United States, United Kingdom, and Canada. METHODS: Data were derived from a large health insurer in the United States, general practices in the United Kingdom, and the Province of Saskatchewan. We identified potential cases of thrombotic thrombocytopenia purpura and hemolytic uremic syndrome in computerized data and verified them by medical record review. We estimated incidence rates for thrombotic thrombocytopenia purpura and hemolytic uremic syndrome together and separately, and we conducted a case-control study to evaluate potential risk factors. RESULTS: The age-sex standardized incidence of thrombotic thrombocytopenia purpura and hemolytic uremic syndrome was higher than previously reported (6.5, 2.2, and 3.2 per million per year in the United States, United Kingdom, and Saskatchewan, respectively), but there was no secular trend. The incidence of thrombotic thrombocytopenia purpura and hemolytic uremic syndrome was higher in women than men. Most cases of hemolytic uremic syndrome occurred before 20 years of age. We confirmed several known risk factors for thrombotic thrombocytopenia purpura and hemolytic uremic syndrome (cancer, bone marrow transplantation, pregnancy). CONCLUSION: The incidence of thrombotic thrombocytopenia purpura and hemolytic uremic syndrome is higher than previously reported but does not appear to be rising. Apparent international differences in incidence could be the result of imprecision in identifying thrombotic thrombocytopenia purpura and hemolytic uremic syndrome in large research databases. |
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Authors:
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David P Miller; James A Kaye; Kathleen Shea; Najat Ziyadeh; Clorinda Cali; Corri Black; Alexander M Walker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 15 ISSN: 1044-3983 ISO Abbreviation: Epidemiology Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-05-06 Completed Date: 2004-05-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: United States |
Other Details:
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Languages: eng Pagination: 208-15 Citation Subset: IM |
Affiliation:
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Ingenix, Newton, Massachusetts 02466, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Great Britain / epidemiology Hemolytic-Uremic Syndrome / epidemiology* Humans Incidence Male Medical Records Systems, Computerized Middle Aged Predictive Value of Tests Purpura, Thrombotic Thrombocytopenic / epidemiology*, etiology, mortality Risk Factors Saskatchewan / epidemiology United States / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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