Document Detail

Incidence of thrombocytopenia in infants born to mothers with idiopathic thrombocytopenic purpura.
MedLine Citation:
PMID:  9581299     Owner:  NLM     Status:  MEDLINE    
Neonatal thrombocytopenia related to maternal idiopathic thrombocytopenic purpura (ITP) is reportedly uncommon but may have severe complications. The present report reviews records of 15 infants born to mothers with ITP during a 10-year period, and the incidence of neonatal thrombocytopenia and the risk of hematological complications is examined. Severe thrombocytopenia (platelets < 50,000/microL) was seen in three infants despite successful therapy with high-dose gamma globulin prior to delivery, which elevated maternal platelet counts. Although the platelet counts of these three infants fell to < 10,000/microL, none had severe complications. Moreover, no infants required treatment such as adrenocorticosteroids, platelets transfusion, or high doses of gamma globulin. No maternal markers predicted the degree of neonatal thrombocytopenia. The risk of complications arising from neonatal thrombocytopenia is low, but careful observation is required for the thrombocytopenic newborn of ITP mothers even when the infant has no bleeding complications at delivery.
T Asano; R Sawa; T Araki; M Yamamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  40     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-20     Completed Date:  1998-05-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  112-5     Citation Subset:  IM    
Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Infant, Newborn
Pregnancy Complications*
Purpura, Thrombocytopenic, Idiopathic / complications*
Retrospective Studies
Thrombocytopenia / epidemiology*,  therapy
gamma-Globulins / therapeutic use
Reg. No./Substance:

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