Document Detail

Incidence of sterile cerebrospinal fluid pleocytosis in infants with urinary tract infection.
MedLine Citation:
PMID:  19490407     Owner:  NLM     Status:  In-Data-Review    
Aim:  To determine the incidence of sterile cerebrospinal fluid (CSF) pleocytosis in infants ≤6 months old with urinary tract infection (UTI). Methods:  Retrospective study of children admitted to a tertiary children's hospital in 2006 and 2007 with UTI who also had a lumbar puncture performed. All urine specimens were tested for anti-microbial activity. Results:  Twelve (11.3%) of 106 infants with UTI had concurrent CSF pleocytosis. None of these patients had anti-microbial activity in the urine, showing that they had not received prior antibiotics. None of the 15 neonates (≤28 days old) with UTI and lumbar puncture had CSF pleocytosis. Antibiotics were stopped after a maximum of 10 days. Conclusion:  Our results are compatible with published reports on the proportion of infants with UTI who have concurrent sterile CSF pleocytosis. We were able to exclude previous antibiotic therapy by measuring urinary anti-microbial activity. Our work supports the hypothesis that CSF pleocytosis in UTI is inflammatory and not because of infection of the central nervous system.
Andrew Ow Yam; David Andresen; Alison M Kesson; David Isaacs
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Publication Detail:
Type:  Journal Article     Date:  2009-05-28
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  45     ISSN:  1440-1754     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2012-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  364-7     Citation Subset:  IM    
Copyright Information:
© 2009 The Authors. Journal compilation © 2009 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
Medical Student, Faculty of Medicine, University of Sydney, Discipline of Paediatrics and Child Health, University of Sydney, Sydney and Department of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
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