| Incidence of seizures associated with the use of acepromazine in dogs undergoing myelography. | |
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MedLine Citation:
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PMID: 22487256 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the frequency of seizures associated with acepromazine administration when used as a premedicant with methadone for dogs undergoing myelography. DESIGN: Retrospective clinical case study. SETTING: University veterinary teaching hospital. ANIMALS: Sixty-six dogs (mixed and pure breeds), aged between 4 months and 15 years, weighing between 3.5-61 kg. All animals were classified as ASA score I or II. INTERVENTIONS: Forty-three animals were premedicated with methadone (0.1-0.5 mg/kg) and acepromazine (0.01-0.05 mg/kg) intramuscularly. Twenty-three animals were premedicated with methadone alone (0.1-0.5 mg/kg) intramuscularly. Anesthesia was induced with propofol intravenously and maintained with isoflurane delivered in 100% oxygen. All animals received a balanced isotonic crystalloid solution intravenously at a rate of 10 mL/kg/h. Blood pressure, end-tidal CO(2) , oxygen saturation, respiratory rate, and heart rate were monitored throughout anesthesia. Animals requiring surgery immediately following myelography were excluded from the study. MEASUREMENTS AND MAIN RESULTS: The frequency of seizures was 14% (CI: 3.6-24.3%) and 13.0% (CI: 0.7-27%) in dogs that received methadone/acepromazine and methadone alone, respectively. There was no significant difference in the frequency of seizures between dogs receiving methadone/acepromazine or methadone alone (P = 1). Analysis of the association of site of injection of the contrast and the frequency of seizures in dogs receiving methadone/acepromazine showed no significant difference in the frequency of seizures following cervical injection (25%; CI: 0.5-24.5%) or lumbar injection (9.7%; CI: -0.7-20.1%). CONCLUSIONS: The administration of acepromazine combined with methadone as a premedicant used with propofol and isoflurane anesthesia did not significantly increase the frequency of seizures following myelography compared to dogs who received methadone alone. |
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Authors:
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Eleanor A Drynan; Peter Gray; Anthea L Raisis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-5 |
Journal Detail:
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Title: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) Volume: - ISSN: 1476-4431 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101152804 Medline TA: J Vet Emerg Crit Care (San Antonio) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Veterinary Emergency and Critical Care Society 2011. |
Affiliation:
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From the Department of Anaesthesia, Murdoch University Veterinary Hospital, Murdoch, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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