| Incidence of scoliosis in beta-thalassemia and follow-up evaluation. | |
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MedLine Citation:
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PMID: 8855465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY DESIGN: One hundred fifteen of 120 patients with beta-thalassemia followed in the thalassemia unit were studied for the presence of scoliosis. Forty-nine of these patients were reevaluated 1 year later. OBJECTIVES: To determine the frequency and the course of scoliosis in beta-thalassemia and to compare the findings with those of patients with idiopathic scoliosis. SUMMARY AND BACKGROUND DATA: There is only one report indicating increased frequency of scoliosis in a limited number of patients with thalassemia. In this study, the authors assessed the frequency of scoliosis in a large sample of patients and followed the evolution of this spinal deformity. METHODS: Patients with beta-thalassemia aged 3-35 years were examined clinically and radiologically for scoliosis. Forty-nine of them were reexamined 1 year later for determination of the evolution of scoliosis. RESULTS: Lateral curves of at least 5 degrees Cobb were found in 77 patients (67%), with a male-to-female ratio of 0.9. Scoliosis of at least 10 degrees was found in 21.7% of the male and 20% of the female patients with thalassemia. The ratio was 1.18 for curves of at least 10 degrees and 0.77 for curves of a smaller magnitude. The most common curve pattern was the left lumbar (35.1%), followed by the double-curve pattern (16.9%). Forty-nine randomly selected patients (42.6%) of the 115 included in the study were reexamined 1 year later. Seven male and 7 female patients (total, 28.6%) showed a progression of at least 5 degrees. Six patients (12.2%) experienced spontaneous improvement of less than 6 degrees. The pattern and the evolution of scoliosis observed in patients with beta-thalassemia differ from those found in Greek children with idiopathic scoliosis. CONCLUSIONS: The findings of this study show that the incidence, evolution, and etiology of scoliosis in beta-thalassemia differ from those of idiopathic scoliosis, indicating that the spinal deformities in patients with beta-thalassemia represents a distinct type of scoliosis. Longer follow-up is needed to investigate the natural history of this type of scoliosis. |
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Authors:
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P Korovessis; D Papanastasiou; M Tiniakou; N G Beratis |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Spine Volume: 21 ISSN: 0362-2436 ISO Abbreviation: Spine Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-12-23 Completed Date: 1996-12-23 Revised Date: 2009-07-09 |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1798-801 Citation Subset: IM |
Affiliation:
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Department of Orthopedics, General Hospital Agios Andreas, Patras, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Distribution Analysis of Variance Child Child, Preschool Disease Progression Female Follow-Up Studies Greece / epidemiology Humans Incidence Male Random Allocation Scoliosis / epidemiology*, etiology, radiography Sex Distribution beta-Thalassemia / complications*, radiography |
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