Document Detail

Incidence and risk factors for subtypes of cerebral infarction in a general population: the Hisayama study.
MedLine Citation:
PMID:  11062284     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: We estimated the incidence of first-ever cerebral infarction in regard to its subtypes and analyzed their risk factors separately in a community-based prospective cohort study in Japan. METHODS: Stroke-free subjects (n=1621) aged >/=40 years were followed up for 32 years from 1961. During this period, 298 cerebral infarctions occurred and were divided into 167 lacunar, 62 atherothrombotic, 56 cardioembolic, and 13 undetermined subtypes of infarction on the basis of clinical information including brain imaging and autopsy findings. RESULTS: The age-adjusted incidence of lacunar infarction (3.8 per 1000 person-years for men and 2.0 for women) was higher than that of atherothrombotic infarction (1.2, 0. 7) and cardioembolic infarction (1.3, 0.5) in both sexes. Time-dependent Cox's proportional hazard analysis revealed systolic blood pressure as well as age to be independent risk factors for all subtypes of cerebral infarction except for cardioembolic infarction in men. Additionally, ST depression on ECG, glucose intolerance, and smoking in men and left ventricular hypertrophy on ECG and body mass index in women remained significant risk factors for lacunar infarction. ST depression was also significantly related to events of atherothrombotic infarction in women. The risk of atrial fibrillation for cardioembolic infarction was outstandingly high in both sexes, and left ventricular hypertrophy and lower total cholesterol were additional risk factors for cardioembolic infarction in women. CONCLUSIONS: In this Japanese population, lacunar infarction was the most common subtype of cerebral infarction and had a greater variety of risk factors, including not only hypertension but also ECG abnormalities, diabetes, obesity, and smoking, than did atherothrombotic infarction or cardioembolic infarction.
Y Tanizaki; Y Kiyohara; I Kato; H Iwamoto; K Nakayama; N Shinohara; H Arima; K Tanaka; S Ibayashi; M Fujishima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  31     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-08     Completed Date:  2000-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2616-22     Citation Subset:  IM    
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Age Factors
Cerebral Infarction / classification,  diagnosis,  epidemiology*
Diabetes Mellitus / epidemiology
Follow-Up Studies
Heart Diseases / epidemiology
Hypertension / epidemiology
Middle Aged
Obesity / epidemiology
Proportional Hazards Models
Risk Factors
Sex Factors
Smoking / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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